Find information on thousands of medical conditions and prescription drugs.

Abciximab

Abciximab (previously known as c7E3 Fab), manufactured by Centocor and distributed by Eli Lilly under the trade name ReoPro®, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. Its mechanism of action is inhibition of glycoprotein IIb/IIIa. more...

Home
Diseases
Medicines
A
8-Hour Bayer
Abacavir
Abamectin
Abarelix
Abciximab
Abelcet
Abilify
Abreva
Acamprosate
Acarbose
Accolate
Accoleit
Accupril
Accurbron
Accure
Accuretic
Accutane
Acebutolol
Aceclidine
Acepromazine
Acesulfame
Acetaminophen
Acetazolamide
Acetohexamide
Acetohexamide
Acetylcholine chloride
Acetylcysteine
Acetyldigitoxin
Aciclovir
Acihexal
Acilac
Aciphex
Acitretin
Actifed
Actigall
Actiq
Actisite
Actonel
Actos
Acular
Acyclovir
Adalat
Adapalene
Adderall
Adefovir
Adrafinil
Adriamycin
Adriamycin
Advicor
Advil
Aerobid
Aerolate
Afrinol
Aggrenox
Agomelatine
Agrylin
Airomir
Alanine
Alavert
Albendazole
Alcaine
Alclometasone
Aldomet
Aldosterone
Alesse
Aleve
Alfenta
Alfentanil
Alfuzosin
Alimta
Alkeran
Alkeran
Allegra
Allopurinol
Alora
Alosetron
Alpidem
Alprazolam
Altace
Alteplase
Alvircept sudotox
Amantadine
Amaryl
Ambien
Ambisome
Amfetamine
Amicar
Amifostine
Amikacin
Amiloride
Amineptine
Aminocaproic acid
Aminoglutethimide
Aminophenazone
Aminophylline
Amiodarone
Amisulpride
Amitraz
Amitriptyline
Amlodipine
Amobarbital
Amohexal
Amoxapine
Amoxicillin
Amoxil
Amphetamine
Amphotec
Amphotericin B
Ampicillin
Anafranil
Anagrelide
Anakinra
Anaprox
Anastrozole
Ancef
Android
Anexsia
Aniracetam
Antabuse
Antitussive
Antivert
Apidra
Apresoline
Aquaphyllin
Aquaphyllin
Aranesp
Aranesp
Arava
Arestin
Arestin
Argatroban
Argatroban
Argatroban
Argatroban
Arginine
Arginine
Aricept
Aricept
Arimidex
Arimidex
Aripiprazole
Aripiprazole
Arixtra
Arixtra
Artane
Artane
Artemether
Artemether
Artemisinin
Artemisinin
Artesunate
Artesunate
Arthrotec
Arthrotec
Asacol
Ascorbic acid
Asmalix
Aspartame
Aspartic acid
Aspirin
Astemizole
Atacand
Atarax
Atehexal
Atenolol
Ativan
Atorvastatin
Atosiban
Atovaquone
Atridox
Atropine
Atrovent
Augmentin
Aureomycin
Avandia
Avapro
Avinza
Avizafone
Avobenzone
Avodart
Axid
Axotal
Azacitidine
Azahexal
Azathioprine
Azelaic acid
Azimilide
Azithromycin
Azlocillin
Azmacort
Aztreonam
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

While Abciximab has a short plasma half life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks. In practice, platelet aggregation gradually returns to normal about 24 to 48 hours after discontinuation of the drug.

Abciximab is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane.

Indications for use

Abciximab is indicated for use in individuals undergoing percutaneous coronary intervention (angioplasty with or without stent placement). The use of abciximab in this setting is associated with a decreased incidence of ischemic complications due to the procedure1 and a decreased need for repeated coronary artery revascularization in the first month following the procedure2.

Pharmacokinetics

Abciximab has a plasma half life of about ten minutes, with a second phase half life of about 30 minutes. However, its effects on platelet function can be seen for up to 48 hours after the infusion has been terminated, and low levels of glycoprotein IIb/IIIa receptor blockade are present for up to 15 days after the infusion is terminated.

Side effects

Many of the side effects of abciximab are due to its anti-platelet effects. This includes an increased risk of bleeding. The most common type of bleeding due to abciximab is gastrointestinal hemorrhage. Thrombocytopenia is a rare but known serious risk.

Read more at Wikipedia.org


[List your site here Free!]


Long-term survival benefit after use of abciximab? - Tips from Other Journals
From American Family Physician, 11/15/02 by Grace Brooke Huffman

Previous studies have shown the benefit of using intravenous platelet glycoprotein IIb/IIIa inhibitors (abciximab) during percutaneous coronary revascularization. In the short term, there was a 38 percent reduction in the rates of postprocedure death and nonfatal myocardial infarction. Long-term benefit has been less well defined, however. Topol and associates conducted an analysis of three large, randomized trials that used abciximab to determine if all-cause mortality was reduced several years after this treatment.

The three trials analyzed by the authors were the Evaluation of c7E3 for the Prevention of Ischemic Complications (EPIC), Evaluation of PTCA to Improve Long-term Outcome by c7E3 GPIIb/IIIa receptor blockade (EPILOG), and Evaluation of IIb/IIIa Platelet Inhibitor for STENTing (EPISTENT). Patients who were undergoing percutaneous coronary revascularization were randomly assigned to receive placebo or abciximab. The follow-up period was three to nine years. If a patient could not be located, the National Death Index was searched, and patients not listed there were assumed to be alive at the end of the study period. The analysis compared all-cause mortality in patients receiving abciximab and patients receiving placebo. If there was no corresponding placebo group (e.g., in the EPISTENT group that had angioplasty plus abciximab), the patients were excluded.

The three-year "completeness rate" for all three studies was 96.6 percent. EPIC followed patients for seven years; 91.7 percent were tracked for the full period. The survival benefit for patients receiving abciximab was significant; the absolute difference in mortality was 1.4 percent (all-cause mortality was 6.4 percent in the placebo group and 5.0 percent in the abciximab group). There was a total of 652 deaths, 308 (12.6 percent) in the placebo groups compared with 344 (10.2 percent) in the abciximab groups. Of the various methods of abciximab administration, the greatest survival benefit occurred in patients who received a bolus dose of abciximab (as compared with a bolus dose plus subsequent infusion).

The authors conclude that abciximab confers short- and long-term survival benefits. Given the fact that there are at least 750,000 percutaneous coronary revascularization procedures every year, use of abciximab is associated with 11,000 fewer deaths annually. Specifically, this figure would equal 14 fewer deaths per 1,000 after three years and 21 fewer deaths per 1,000 after five years.

COPYRIGHT 2002 American Academy of Family Physicians
COPYRIGHT 2002 Gale Group

Return to Abciximab
Home Contact Resources Exchange Links ebay