Acamprosate's chemical structure
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Acamprosate

Acamprosate, also known by the brand name Campral, is a drug used for treating alcohol dependence. It balances chemicals in your brain that are otherwise unbalanced due to alcoholism. Reports indicate that Acamprosate only works with a combination of attending support groups and abstinence from alcohol. Certain serious side effects include allergic reactions, irregular heartbeats, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. more...

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While the FDA in the United States approved this drug in July 2004, this drug has been legal in Europe since 1989. Upon the FDA's approval, they have released this statement:

"While its mechanism of action is not fully understood, Campral is thought to act on the brain pathways related to alcohol abuse. Campral was demonstrated to be safe and effective by multiple placebo-controlled clinical studies involving alcohol-dependent patients who had already been withdrawn from alcohol, (i.e., detoxified). Campral proved superior to placebo in maintaining abstinence (keeping patients off alcohol consumption), as indicated by a greater percentage of acamprosate-treated subjects being assessed as continuously abstinent throughout treatment. Campral is not addicting and was generally well-tolerated in clinical trials. The most common adverse events reported for patients taking Campral included headache, diarrhea, flatulence, and nausea."

The brand of this drug, Campral, is manufactured by Merch-Lipha in France. They are sold as 333mg white and odorless tablets of Acamprosate calcium, which is the equivalent of 300mg of Acamprosate.

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Medication to Treat Alcoholism
From Nurse Practitioner, 11/1/04

Acamprosate (Campral) received FDA approval for the treatment of alcohol-dependent individuals seeking to remain alcohol-free after cessation of drinking.This is the first new drug approved for alcohol abuse in a decade. Acamprosate is a product of Lipha Pharmaceutical, Lyon, France.

Acamprosate should be used as part of a comprehensive management program that includes psychosocial support. It may not be effective in patients who actively drink at the start of treatment, or in patients who abuse other substances in addition to alcohol.

Clinical trials of alcohol-dependent patients who had already been withdrawn from alcohol showed that the drug is safe and effective. These studies showed that acamprosate was superior to placebo in maintaining abstinence.

Copyright Springhouse Corporation Nov 2004
Provided by ProQuest Information and Learning Company. All rights Reserved

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