Pioglitazone chemical structure
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Actos

In medicine and pharmacology, pioglitazone is a member of the drug class of the thiazolidinediones.

It is being marketed as Actos® by the pharmaceutical companies Takeda and Eli Lilly.

Like other thiazolidinediones, its mechanism of action is by activation the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ.

Side-effects and contraindications

See main article: thiazolidinedione
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Safety profile of Takeda's Actos receives favorable reviews
From Drug Store News, 5/17/99

On the day following the Avandia recommendation, the same Food and Drug Administration panel recommended approval of Takeda Pharmaceuticals' drug Actos. The FDA hasn't yet finished its review of the data on Actos' effectiveness, so the agency only asked the panel to comment on Actos' safety profile.

In Takeda's six U.S. studies, more than 2,500 patients took Actos; of those patients, none developed jaundice or had severe elevation in liver enzyme levels. The panel agreed that concerning safety, Actos and Avandia should be considered similar. In a written statement issued at the FDA panel meeting, Warner-Lambert said if the two drugs are approved, it will conduct head-to-head trials comparing them to Rezulin. More than 100 clinical trials are currently under way involving Rezulin for a variety of therapeutic indications.

Takeda has also partnered with a giant in the diabetes market, Eli Lilly, to co-promote the drug for sale in the United States.

COPYRIGHT 1999 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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