Adapalene chemical structure
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Adapalene

Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma Laboratories under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water. more...

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History

Adapalene was approved in 1996 by the FDA for use in the treatment of acne.

Available forms

Adapalene is available in four different forms: gel, solution, pledglets and cream.

Indications

Adapalene is indicated for acne vulgaris.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

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Adapalene for Acne - Brief Article
From Family Pratice News, 5/1/01

Adapalene was as effective as tretinoin for treating mild to moderate acne and produced less irritation, Dr. W.J. Cunliffe said in a poster session at the annual meeting of the American Academy of Dermatology.

A total of 409 patients ranging in age from 12 to 25 were randomized to 10 weeks of treatment with 0.01% adapalene gel or 0.05% tretinoin cream. The number of inflammatory lesions fell by 38% in the adapalene groups and by 37% in the tretinoin group. The number of noninflammatory lesions was reduced by 51% in each group, said Dr. Cunliffe of the Skin Research Centre, Leeds (England) General Infirmary.

Irritation was the greatest in both groups during the first week. The adapalene group had less erythema at weeks 1 and 6, less dryness at weeks 1 and 3, and less desquamation at weeks 1, 3, and 6.

COPYRIGHT 2001 International Medical News Group
COPYRIGHT 2001 Gale Group

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