Adapalene chemical structure
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Adapalene

Adapalene is a chemical compound that is primarily used as a topical treatment for acne. It is a retinoid, meaning it is chemically similar to Vitamin A, and is currently sold by Galderma Laboratories under the trade name Differin in many different forms. In pure form, adapalene is a white to off white powder that is insoluble in water. more...

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History

Adapalene was approved in 1996 by the FDA for use in the treatment of acne.

Available forms

Adapalene is available in four different forms: gel, solution, pledglets and cream.

Indications

Adapalene is indicated for acne vulgaris.

Pharmacodynamics

Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. The exact mode of action of adapalene is unknown.

Pharmacokinetics

Adapalene is applied topically to the skin, and its absorption through this medium is very low. Only trace amounts of adapalene have been found in the plasma of chronically treated patients.

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Adapalene Over Retin A
From OB/GYN News, 5/15/00 by Sally Koch Kubetin

Adapalene gel worked just as quickly and effectively as Retin A Micro in clearing acne, but it caused less dryness, stinging, burning, erythema, and scaling in a 12-week trial that included 168 patients.

"I don't think for a second there is an irritant gene that Retin A turns on and adapalene doesn't," Dr. Brad Amos said at an acne update at the annual Hawaii dermatology seminar sponsored by the Skin Disease Education Foundation.

Instead, he attributes adapalene's gentle clinical profile to the drug's profound anti-inflammatory properties.

The investigator-blinded study found no significant difference in the number of comedones or the total lesion count when patients using 0.1% adapalene were compared with those using 0.1% Retin A Micro.

But dryness was less pronounced in patients using adapalene each time they were examined, at weeks 1, 2, 6, and 12. Stinging, burning, erythema, and scaling were similarly less of a problem with adapalene, Dr. Amos, a dermatologist in private practice in Wexford, Pa., reported at the seminar, also sponsored by the Cleveland Clinic Foundation.

COPYRIGHT 2000 International Medical News Group
COPYRIGHT 2001 Gale Group

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