Melphalan chemical structure
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Alkeran

Melphalan hydrochloride ( AlkeranĀ®) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. It is used primarily to treat multiple myeloma and ovarian cancer, and occasionally malignant melanoma. Otherwise known as L-Phenylalanine Mustard, or L-PAM, melphalan is a phenylalanine derivative of mechlorethamine. The agent was first investigated as a possible drug for use in melanoma however it did not work but was found to be of use in myeloma. more...

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Administration

Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight.

Side effects

Common side effects include:

  • Nausea and vomiting
  • Bone marrow suppression, including
    • Decreased white blood cell count causing increased risk of infection
    • Decreased platelet count causing increased risk of bleeding

Less common side effects include:

  • Severe allergic reactions
  • Scarring of lung tissue (usually only with prolonged use)
  • Hair loss
  • Rash
  • Itching

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Spector, Roseman & Kodroff, P.C. Say Federal Judge Allows Consumers to Continue Class Action for Overpayment of Medicare Part B Prescription Drugs
From Business Wire, 8/19/05

BOSTON -- In a national class action lawsuit filed by Spector, Roseman & Kodroff, P.C. on behalf of consumers and third party payors claiming prescription drug overpayments, U.S. District Judge Patti B. Saris indicated that she would certify a nationwide class of Medicare Part B beneficiaries, if enough consumers appeared and filed complaints by October 17, 2005.

According to Jeffrey L. Kodroff, one of the lead counsel for the plaintiffs in In re Pharmaceutical Industry Average Wholesale Price Litigation, "Judge Saris offered a clear roadmap for class certification to consumers covered by Medicare Part B who have overpaid for physician administered drugs manufactured by GlaxoSmithKline, Bristol-Meyers Squibb, AstraZeneca, Schering-Plough and Johnson & Johnson because the companies fraudulently created, manipulated and inflated the cost of prescription medication to consumers by overstating the average wholesale price." In case filings, Kodroff, from the Philadelphia-based law firm of Spector, Roseman & Kodroff, P.C., alleged that the defendants knowingly inflated the average wholesale price or AWP to cause beneficiaries of the Medicare Part B program, other consumer patients and third party payors to overpay for drugs used in treating cancer, rheumatoid arthritis and other chronic illnesses.

Kodroff said Judge Saris stated earlier this week that she would certify a nationwide class of Medicare Part B beneficiaries once the complaint is amended to add individual class representatives who pay all or a portion of their Medicare Part B co-payment for their drugs. At that time she also certified a Massachusetts statewide class for third party payors, offering supplemental insurance to cover Medicare Part B co-pays and a Massachusetts statewide class for any payments for brand name and generic drugs, outside of the Medicare Part B arena, if the reimbursement was explicitly based on average wholesale price.

The prescription drugs mentioned in this complaint include: Alkeran, Blenoxane, Cytoxan, Etopophos, Kytril, Navelbine, Paraplatin, Procrit, Remicade, Rubex, Taxol, Vepesid, Zofran, Zoladex and Zovirax.

For more information about this lawsuit, and to determine if you are eligible to participate in these actions, contact Jeffrey L. Kodroff or John A. Macoretta at Spector, Roseman & Kodroff, P.C. at 1-888-844-5862. For a copy of this order visit www.srk-law.com.

COPYRIGHT 2005 Business Wire
COPYRIGHT 2005 Gale Group

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