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Altace

Ramipril (marketed as Tritace® or Altace®) is an angiotensin converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. ACE inhibitors lower the production of Angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood easier, and increasing blood flow due to more blood being pumped into and through bigger passageways. more...

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Ramipril is a prodrug and is converted to the active metabolite ramiprilat by liver esterase enzymes. Ramiprilat is mostly excreted by the kidneys. The half-life of ramiprilat is variable (3 - 16 hours), and is prolonged by heart and liver failure, as well as kidney failure.

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Altace gets expanded indication - Cardiovascular medicine now approved - Brief Article
From Drug Store News, 11/13/00

Altace (ramipril) is now approved to reduce risk of stroke, heart attack and death from cardiovascular causes. Altace is marketed jointly by Wyeth-Ayerst Laboratories and King Pharmaceuticals. Dosage is a 10-mg capsule once daily.

In the Heart Outcomes Prevention Evaluation study, in which 9,297 patients aged 55 and older were evaluated for more than four years, rates of reduction of cardiovascular events reported were: 32 percent in stroke, 20 percent in heart attack, 26 percent for cardiovascular death, 22 percent among all patents at risk for these events, and a 16 percent reduction in incidence of death from any cause. Benefits were seen after just one year of treatment.

Altace, an angiotensin-converting enzyme inhibitor, was first approved to treat hypertension in 1991 and later for congestive heart failure following a heart attack.

COPYRIGHT 2000 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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