Amlodipine chemical structure
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Amlodipine

Amlodipine (as besylate or malleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc® and under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. more...

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Side effects

Some side effects of the use of amlodipine may be:

  • Very often: peripheral edema (feet and ankles) - in 1 of 10 users
  • Often: dizzyness, palpitations, muscle, stomach or headache, dyspepsia, nausea - in 1 in 100 users
  • Sometimes: blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia - in 1 in 1,000 users
  • Rarely: erratic behavior, hepatitis, jaundice - in 1 in 10,000 users
  • Very rarely: hyperglycemia, tremor, Stevens-Johnson syndrome - in 1 in 100,000 users

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Sumitomo Chemical Files Suit Against Pfizer for Amlodipine Besilate
From JCNN News Summaries, 11/2/05

Tokyo, Japan, Nov 2, 2005 - (JCNN) - Sumitomo Chemical announced on November 1 that it and its subsidiary Dainippon Sumitomo Pharma have jointly filed suit against Pfizer in the Tokyo District Court on the same day.

In response to a preliminary injunction petition filed by Pfizer in October, the two companies seek a declaratory judgment that their right to manufacture and sell amoldipine besilate remains valid. Amoldipine besilate is a hypertension drug discovered by Pfizer.

Since 1991, Pfizer and Sumitomo Pharamceuticals, one of the two predecessor companies of Dainippon Sumitomo Pharma, have entered into a licensing agreement for amoldipine bestilate.

Sumitomo Pharmaceuticals has been marketing the agent under the trade name of Amoldin since then.

Source: JCN http://www.japancorp.net

Copyright [c] 2005 Japan Corporate News Network. All rights reserved.

COPYRIGHT 2005 Japan Corporate News Network K.K.
COPYRIGHT 2005 Gale Group

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