Amlodipine chemical structure
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Amlodipine

Amlodipine (as besylate or malleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc® and under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. more...

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Side effects

Some side effects of the use of amlodipine may be:

  • Very often: peripheral edema (feet and ankles) - in 1 of 10 users
  • Often: dizzyness, palpitations, muscle, stomach or headache, dyspepsia, nausea - in 1 in 100 users
  • Sometimes: blood disorders, development of breasts in men (gynecomastia), impotence, depression, insomnia, tachycardia - in 1 in 1,000 users
  • Rarely: erratic behavior, hepatitis, jaundice - in 1 in 10,000 users
  • Very rarely: hyperglycemia, tremor, Stevens-Johnson syndrome - in 1 in 100,000 users

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Amlodipine lowers blood pressure without affecting cerebral blood flow as measured by single photon emission computed tomography in elderly hypertensive
From Age and Ageing, 9/1/99 by N Pandita-Gunawardena

Aim: to evaluate the effect of amlodipine on blood pressure and cerebral blood flow in elderly subjects with mild to moderate hypertension. Methods: a double-blind, parallel group study of 26 patients. After a 4-week placebo run-in period, amlodipine (5-10 mg) or matching placebo was given once daffy for 8 weeks. Results: amlodipine significantly reduced blood pressure compared with baseline. Diastolic blood pressure was significantly reduced by amlodipine compared with placebo (P < 0.02 to P < 0.01). Ambulatory blood pressure monitoring showed that blood pressure control was sustained over the 24-h dosing interval. Relative regional cerebral blood flow, assessed using single photon emission computed tomography, was not significantly affected by amlodipine. Three placebo patients, but no amlodipine patients, withdrew because of adverse events. Conclusion: amlodipine was a well-tolerated and effective antihypertensive agent, and did not reduce regional cerebral blood flow in elderly hypertensive patients.

COPYRIGHT 1999 Oxford University Press
COPYRIGHT 2000 Gale Group

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