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Anagrelide

Anagrelide (Agrylin®, Shire) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). It works by inhibiting the maturation of megakaryocytes into platelets. The exact mechanism of action is unclear, although it is known to be a potent (IC50 = 36nM) inhibitor of phosphodiesterase-III. more...

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In a 2005 head-to-head study (Harrison et al) hydroxyurea was found to be superior to anagrelide for the management of ET, with a small increase in the number of cases of myelofibrosis.

Side Effects

Headache, diarrhea, unusual weakness, nausea, dizziness may occur. If these persist or worsen, notify your doctor. Notify your doctor promptly if you develop: shortness of breath, swelling, stomach or chest pain, rash, itching, tingling sensations. Unlikely but report promptly: irregular or fast heartbeat, one-sided muscle weakness in arms or legs, black stools, fainting, mental changes, vision problems, unusual bleeding or bruising, pink-colored urine. Very unlikely but report promptly: unusual change in the amount of urine. If you notice other effects not listed above, contact your doctor or pharmacist.

Reference

  • Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR; United Kingdom Medical Research Council Primary Thrombocythemia 1 Study. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005;353:33-45. PMID 16000354.

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Barr Pharmaceuticals
From Drug Store News, 5/2/05 by James Frederick

Barr Pharmaceuticals received final FDA approval for anagrelide HCl capsules, 0.5 mg and 1 mg, the generic version of Shire Pharmaceutical Group's Agrylin, indicated for treating thrombocythemia, secondary to myeloproliferative disorders. Agrylin generated 2004 annual sales of $107 million, based on IMS data for the 12 months ended in February. Barr also received final FDA approval and 180 days marketing exclusivity for fexofenadine HCl 60 mg and pseudoephedrine HCl 120 mg extended-release tablets, the generic version of Aventis Pharmaceuticals' Allegra-D 12-hour tablets, with annual branded sales of about $434 million for the 12 months ended in February, according to IMS.

COPYRIGHT 2005 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2005 Gale Group

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