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Anagrelide

Anagrelide (Agrylin®, Shire) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). It works by inhibiting the maturation of megakaryocytes into platelets. The exact mechanism of action is unclear, although it is known to be a potent (IC50 = 36nM) inhibitor of phosphodiesterase-III. more...

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In a 2005 head-to-head study (Harrison et al) hydroxyurea was found to be superior to anagrelide for the management of ET, with a small increase in the number of cases of myelofibrosis.

Side Effects

Headache, diarrhea, unusual weakness, nausea, dizziness may occur. If these persist or worsen, notify your doctor. Notify your doctor promptly if you develop: shortness of breath, swelling, stomach or chest pain, rash, itching, tingling sensations. Unlikely but report promptly: irregular or fast heartbeat, one-sided muscle weakness in arms or legs, black stools, fainting, mental changes, vision problems, unusual bleeding or bruising, pink-colored urine. Very unlikely but report promptly: unusual change in the amount of urine. If you notice other effects not listed above, contact your doctor or pharmacist.

Reference

  • Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR; United Kingdom Medical Research Council Primary Thrombocythemia 1 Study. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005;353:33-45. PMID 16000354.

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Eon Labs Receives Final Approval for Anagrelide HCl Capsules and Will Begin Shipping Immediately
From Business Wire, 4/18/05

LAKE SUCCESS, N.Y. -- Eon Labs, Inc. (Nasdaq: ELAB) announced today that it received final approval for Anagrelide HCl capsules, the generic equivalent of Agrylin(R)* capsules, in the same strengths as the brand, 0.5mg and 1mg. The Company will begin shipping Anagrelide HCl capsules immediately.

Eon Labs is a generic pharmaceutical company specializing in developing, licensing, manufacturing, selling and distributing a broad range of prescription pharmaceutical products. For press releases and other company information, visit the Eon Labs, Inc. website at www.eonlabs.com.

Safe Harbor Statement under the U.S. Private Securities Litigation Reform Act of 1995: This release contains statements that are forward-looking in nature which express the beliefs and expectations of management. Such statements are based on current plans, estimates and expectations and involve a number of known and unknown risks, uncertainties and other factors that could cause the Company's future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. These factors and additional information are discussed in the Company's filings with the Securities and Exchange Commission and statements in this release should be evaluated in light of these important factors. Although we believe that these statements are based upon reasonable assumptions, we cannot guarantee future results. Forward-looking statements speak only as of the date on which they are made, and the Company undertakes no obligation to update publicly or revise any forward-looking statement, whether as a result of new information, future developments or otherwise.

*Agrylin(R) is a registered trademark of Shire US, Inc. which is not affiliated with Eon Labs, Inc.

COPYRIGHT 2005 Business Wire
COPYRIGHT 2005 Gale Group

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