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Anastrozole

Anastrozole (Arimidex) is a drug used to treat breast cancer in post-menopausal women. It is used in both adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It works by decreasing the amount of estrogen that the body makes. more...

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Anastrozole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens (produced by women in the adrenal glands) to oestrogen.

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial represents a long-term follow-up study of 9366 women with localized breast cancer who received either anastrozole or/and tamoxifen. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor positive.

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Anastrozole deemed cost-effective
From OB/GYN News, 2/15/05 by Bruce Jancin

SAN ANTONIO -- Anastrozole is a costeffective alternative to generic tamoxifen for primary adjuvant therapy in postmenopausal women with early-stage breast cancer, according to a new economic analysis.

Based upon the 68-month efficacy and safety data from the Arimidex, Tamoxifen. Alone or Together (ATAC) trial--see accompanying story--5 years of adjuvant anastrozole cost an estimated $23,740 per quality-adjusted life-year gained beyond that achieved with 5 years of tamoxifen, Gershon Y. Locker, M.D., reported at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.

That's well within the bounds of what's considered reasonably cost-effective and reimbursable by U.S. health care standards, which variously define the threshold for cost-effectiveness as $50,000-$100,000 per quality-adjusted life-year, noted Dr. Locker of Evanston (Ill.) Northwestern Healthcare and Northwestern University.

The estimated incremental cost-effectiveness for anastrozole compared to tamoxifen was $29,132 per life-year gained without considering quality of life, the on cologist added.

His analysis used published (2004 Drug Topics Red Book) wholesale acquisition costs of $6.56/day for anastrozole (Arimidex) and $1.33/day for generic tamoxifen. The study factored in the direct medical costs of the increased rates of recurrent breast cancer, stroke, venous thromboembolism, and other adverse events associated with tamoxifen therapy, as well as the greater fracture risk entailed in anastrozole therapy.

COPYRIGHT 2005 International Medical News Group
COPYRIGHT 2005 Gale Group

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