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Anosmia

Anosmia is the lack of olfaction, or a loss of the sense of smell. It can be either temporary or permanent. A related term, hyposmia refers to a decrease in the ability to smell. Some people may be anosmic for one particular odor. This is called "specific anosmia" and may be genetically based. Anosmia can be diagnosed by doctors by using scratch-n-sniff odor tests or by using commonly available odors such as coffee, lemon, and cinnamon. more...

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It should be emphazised that there are no more than 5 dictinctive tastes: salty, sour, sweet, bitter, and umami. The 10,000 different scents humans usually recognize are lost with the loss of olfaction.

A temporary loss of smell can be caused by a stuffy nose or infection. In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose, or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell (see olfactory system). The lack of the sense of smell at birth, usually due to genetic factors, is referred as congenital anosmia. Anosmia may be an early sign of degenerative brain diseases such as Parkinson's disease and Alzheimer's disease. Another specific cause of permanent loss could be from damage to olfactory receptor neurons due to use of zinc based nasal sprays .

While termed as a disability, anosmia is often viewed in the medical field as a trivial problem. However, the condition can have a number of detrimental effects . Patients with anosmia may find food less appetizing. Loss of smell can also be dangerous because it hinders the detection of gas leaks, fire, and spoiled food. The common view of anosmia as trivial can make it more difficult for a patient to receive the same types of medical aid as someone who is blind, deaf, or mute.

Losing an established and sentimental smell memory (e.g. the smell of grass, of a toy, of a grandparent's attic, of a particular book, of loved ones, or of oneself) has been known to cause feelings of depression.

Loss of olfaction may lead to the loss of libido, even to the point of impotency, which often preoccupies younger male Anosmics.

Scientists involved in anosmia research include Richard Doty.

Associated conditions

  • Kallmann syndrome
  • zinc deficiency
  • Parkinson's disease
  • Alzheimer's disease

Read more at Wikipedia.org


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Therapy for acute bacterial sinusitis
From OB/GYN News, 3/1/05 by Elizabeth Mechcatie

Acute bacterial sinusitis is usually preceded by a viral infection of the upper respiratory tract. Because experts agree that the indiscriminate use of antibiotics for sinusitis has contributed to the emergence of resistant organisms, antibiotic therapy should be reserved for patients who have clear and severe symptoms of bacterial disease.

Signs and symptoms suggestive of bacterial sinusitis include disease that worsens after 5-7 days or persists for 7 days or more; others are nasal drainage or congestion, facial pressure or pain (especially when unilateral and focused over a sinus), hyposmia or anosmia, fever, cough, fatigue, maxillary dental pain, and ear pressure or fullness.

Studies have shown that most cases of acute bacterial sinusitis will resolve spontaneously and that, on average, antibiotic therapy will reduce the duration of symptoms by only 1 day. Nevertheless, two sets of guidelines published over the past 3 years justify the use of antibiotic therapy in some patients with severe or persistent symptoms.

These two sets of guidelines differ in important respects: The guidelines issued by the American College of Physicians in 2001 mention only three antibiotics--amoxicillin, doxycycline, and trimethoprim-sulfamethoxazole (TMP-SMX)--because these are the only three drugs that have been studied in well-controlled clinical trials in sinusitis (Ann. Intern. Med. 2001;134:495-7).

The other guidelines were issued by the Sinus and Allergy Health Partnership, a group sponsored by the American Academy of Otolaryngic Allergy, the American Academy of Otolarngology-Head and Neck Surgery, and the American Rhinologic Society, in consultation with the Centers for Disease Control and Prevention, the Food and Drug Administration, and experts in infectious disease and other pertinent fields. The guidelines evaluated 19 antibiotics based on a theoretic analysis that incorporated pharmacokinetic and pharmacodynamic data from clinical trials, pathogen distribution, and in vitro activity of the various agents against the three predominant pathogens: Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis (Otolaryngol. Head Neck Surg. 2004;130 [suppl. 1]:1-45).

These guidelines include separate recommendations for people who have had recent antibiotic exposure (and thus are likely to harbor resistant organisms) and for people who are allergic to penicillin. Furthermore, the guidelines suggest both initial therapies and those best reserved for more severe disease or for patients who have failed first-line treatment.

Most experts agree that it's usually better to start with the simpler, less expensive antibiotics with which clinicians are likely to have the most familiarity, such as amoxicillin, amoxicillin/clavulanate, or TMP-SMX, reserving fluoroquinolones and cephalosporins for more severe or resistant disease. The macrolides have a relatively poor side effect profile and are predicted to have only a 77% clinical efficacy, and so are omitted from the list below.

Primary care physicians may consider referring patients to an otolaryngologist if symptoms persist for longer than 72 hours after the initiation of antibiotic therapy.

Amoxicillin, amoxicillin/clavulanate, and the cephalosporins are safe at any time during pregnancy or while nursing. The fluoroquinolones, rifampin plus clindamycin, and TMP-SMX are safe during nursing (avoid TMP-SMX if the infant is premature or jaundiced or has glucose-6-phosphate dehydrogenase [G6PD] deficiency), but should be avoided during the first trimester of pregnancy, although the TMP-SMX risk can be lowered with a daily multivitamin containing 1 mg folic acid. Doxycycline is contraindicated during the second and third trimesters but is safe during nursing.

More information on the diagnosis and treatment of acute bacterial sinusitis can be found in a recent review of the topic (N. Engl. J. Med. 2004;351:902-10).

Elizabeth Mechcatie, Editor

Robert Finn, Writer

COPYRIGHT 2005 International Medical News Group
COPYRIGHT 2005 Gale Group

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