Disulfiram chemical structure
Find information on thousands of medical conditions and prescription drugs.

Antabuse

Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are AntabuseĀ® and AntabusĀ®. more...

Home
Diseases
Medicines
A
8-Hour Bayer
Abacavir
Abamectin
Abarelix
Abciximab
Abelcet
Abilify
Abreva
Acamprosate
Acarbose
Accolate
Accoleit
Accupril
Accurbron
Accure
Accuretic
Accutane
Acebutolol
Aceclidine
Acepromazine
Acesulfame
Acetaminophen
Acetazolamide
Acetohexamide
Acetohexamide
Acetylcholine chloride
Acetylcysteine
Acetyldigitoxin
Aciclovir
Acihexal
Acilac
Aciphex
Acitretin
Actifed
Actigall
Actiq
Actisite
Actonel
Actos
Acular
Acyclovir
Adalat
Adapalene
Adderall
Adefovir
Adrafinil
Adriamycin
Adriamycin
Advicor
Advil
Aerobid
Aerolate
Afrinol
Aggrenox
Agomelatine
Agrylin
Airomir
Alanine
Alavert
Albendazole
Alcaine
Alclometasone
Aldomet
Aldosterone
Alesse
Aleve
Alfenta
Alfentanil
Alfuzosin
Alimta
Alkeran
Alkeran
Allegra
Allopurinol
Alora
Alosetron
Alpidem
Alprazolam
Altace
Alteplase
Alvircept sudotox
Amantadine
Amaryl
Ambien
Ambisome
Amfetamine
Amicar
Amifostine
Amikacin
Amiloride
Amineptine
Aminocaproic acid
Aminoglutethimide
Aminophenazone
Aminophylline
Amiodarone
Amisulpride
Amitraz
Amitriptyline
Amlodipine
Amobarbital
Amohexal
Amoxapine
Amoxicillin
Amoxil
Amphetamine
Amphotec
Amphotericin B
Ampicillin
Anafranil
Anagrelide
Anakinra
Anaprox
Anastrozole
Ancef
Android
Anexsia
Aniracetam
Antabuse
Antitussive
Antivert
Apidra
Apresoline
Aquaphyllin
Aquaphyllin
Aranesp
Aranesp
Arava
Arestin
Arestin
Argatroban
Argatroban
Argatroban
Argatroban
Arginine
Arginine
Aricept
Aricept
Arimidex
Arimidex
Aripiprazole
Aripiprazole
Arixtra
Arixtra
Artane
Artane
Artemether
Artemether
Artemisinin
Artemisinin
Artesunate
Artesunate
Arthrotec
Arthrotec
Asacol
Ascorbic acid
Asmalix
Aspartame
Aspartic acid
Aspirin
Astemizole
Atacand
Atarax
Atehexal
Atenolol
Ativan
Atorvastatin
Atosiban
Atovaquone
Atridox
Atropine
Atrovent
Augmentin
Aureomycin
Avandia
Avapro
Avinza
Avizafone
Avobenzone
Avodart
Axid
Axotal
Azacitidine
Azahexal
Azathioprine
Azelaic acid
Azimilide
Azithromycin
Azlocillin
Azmacort
Aztreonam
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Under normal metabolism, alcohol is broken down in the liver by the enzyme alcohol dehydrogenase to acetaldehyde, which is then converted by the enzyme acetaldehyde dehydrogenase to the harmless acetic acid. Disulfiram blocks this reaction at the intermediate stage by blocking the enzyme acetaldehyde dehydrogenase. After alcohol intake under the influence of disulfiram the concentration of acetaldehyde in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. As acetaldehyde is one of the major causes of the symptoms of a "hangover" this produces immediate and severe negative reaction to alcohol intake. Some 5-10 minutes after alcohol intake, the patient may experience the effects of a severe hangover for a period of 30 minutes up to several hours.

Disulfiram should not be taken if alcohol has been consumed in the last 12 hours. There is no tolerance to disulfiram: the longer it is taken, the stronger its effects. As disulfiram is absorbed slowly through the digestive tract and eliminated slowly by the body the effects may last for up to 2 weeks after the initial intake. Clearly, patients must be fully informed about the disulfiram-alcohol reaction.

The drug's action was discovered by accident in the 1940s in the Danish drug company Medicinalco: workers testing the substance, which was intended to treat parasitic diseases, on themselves reported severe symptoms after alcohol consumption.

One weakness with Disulfiram and similar treatments is that if not taken under supervision an alcoholic will often not stick to the treatment, since it is easier to give up the drug than alcohol. Even when strictly taken the negative effects will rarely break the drinking patterns of a chronic alcoholic. In some extreme cases, patients with subcutaneous disulfiram tablet implants have been known to cut or dig out the tablet to avoid its effects. For these reasons disulfiram is not in itself a cure for alcoholism and is usually only indicated for select patients who wish to remain in an enforced state of sobriety during other forms of treatment, such as support groups and psychotherapy.

Similarly acting substances

Coprine, a closely related chemical having the same metabolic effects, occurs naturally in several edible mushroom species, such as the inky cap.

Temposil, or citrated calcium carbamide, has the same function as Antabuse but is weaker and safer.

Read more at Wikipedia.org


[List your site here Free!]


Patient meds … more important than you think
From Dental Assistant, The, 9/1/02 by Diane Chandler

This is the kind of story that makes you upset. Jeff is an oral surgery resident in an urban hospital with a dental clinic. One day in the clinic, Jeff heard screaming in one of the treatment rooms and went to see if he could be of some assistance. There he saw an 8-year-old boy who was having a tooth extracted. The first year resident trying to operate on the boy was having a really hard time--the tooth just wouldn't numb up. Jeff reviewed the boy's health history and, although the AIDS box on the questionnaire wasn't checked, Jeff was able to quickly zero in on the problem.

The mother of the child was pressed to disclose any debilitating illness her son might have, but repeatedly responded with "none". Jeff next questioned her about the answers she gave on the health history questionnaire. Knowing that one of the medications she indicated her son was taking was a very current medication for the treatment of AIDS, he was finally able to get the mother to disclose that her son had AIDS.

The mother confessed that she just wanted the tooth extracted because he was constantly crying and keeping her up at night. They did not extract the boy's tooth that day but made an appointment for him to have his tooth extracted under general anesthetic in a hospital operating room where they would be prepared for any emergency that might occur.

The dental assistant is the front line for patients coming into the practice. Would the average dental assistant have had any clue that the medication listed was a medication for the treatment of AIDS? The answer is no. It is the responsibility of every health professional to get the most accurate and complete health history, and that includes questioning patients' medications. Further, it includes knowledge of current medications so that you know what questions to ask.

We are taught to treat all patients as if they had AIDS, and so the mother's omission probably would not have made a difference in what was done or the way it was done, but it certainly might have made a difference in another way.

For whatever reason, the mother did not let the resident know the status of her son's health, and because of that her son was traumatized. If one was familiar with the current meds used to treat AIDS, then that child could have been shielded from needlessly suffering pain.

So often in the assisting profession we update our knowledge of current medications but for some reason it seems that the current drugs for AIDS are rarely listed in these updates. Because it is the responsibility of everyone in the health care field to keep up to date, we have reviewed the approved antiretroviral agents for the treatment of HIV infection. They are listed in a chart first published in The Rx Consultant. Because new medications are constantly being introduced, this is by no means an exhaustive list; but it is a current one. Read on and be current!

Diane Chandler, CDA has been practicing in the dental field for 15 years. Every February she does a public service cable program on dental oral hygiene.

Michael Palmer, RPh is a 2000 graduate of Wayne State University School of Pharmacy and Allied Health Professions. He is presently employed full-time at St. John's Hospital and Medical Center. His previous publication was entitled "Appropriate Use of Stress Ulcer Prophylaxix in Surgical Intensive Care Patients".

Chart used with the permission of "The Rx Consultant": www.rxconsultant.com

COPYRIGHT 2002 American Dental Assistants Association
COPYRIGHT 2003 Gale Group

Return to Antabuse
Home Contact Resources Exchange Links ebay