Minocycline chemical structure
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Arestin


Minocycline hydrochloride, also known as minocycline, is a member of the broad spectrum tetracycline antibiotics, and has a broader spectrum than the other members. As a result of its long half-life it generally has serum levels 2-4 times that of most other tetracyclines (150 mg giving 16 times the activity levels compared to 250 mg of tetracycline at 24-48 hours). more...

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It is marketed under several trade names, including Minomycin, Minocin, Arestin, and Dynacin.

Indications

It is primarily used to treat acne and rosacea as the once daily 100mg doasage is far easier for patients than the four times a day required with Tetracycline or Oxytetracycline.

Although minocycline's broader spectrum of activity, compared to other members of the group, includes activity against Neisseria meningitidis, its use as a prophylaxis is no longer recomended because of side effects (dizziness and vertigo).

Cautions and Side effects

In additon to those common to the Tetracycline antibiotics group, minocycline may be used in renal impairment, but may aggrevate systemic lupus erythematosus. ( and ).

Possible additional indications

Current research is examining the possible neuroprotective effects of minocycline against progression of Huntington's Disease, an inherited neurodegenerative disorder. (Research is summarized here and here.) The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase , an inflammatory enzyme associated with brain aging .

Read more at Wikipedia.org


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Personal Products Company Completes Acquisition of REMBRANDT® Brand From The Gillette Company
From PR Newswire, 12/21/05

SKILLMAN, N.J., Dec. 21 /PRNewswire-FirstCall/ -- Personal Products Company, a Johnson & Johnson company, announced today that it has completed its acquisition of the REMBRANDT(R) Brand of oral care products from The Gillette Company. The acquisition had been announced on Oct. 24, 2005.

The terms of the transaction were not disclosed.

The REMBRANDT(R) Brand equity is based in tooth whitening products. Personal Products Company has acquired all the consumer and professionally dispensed REMBRANDT(R) Brand products, including whitening toothpastes, whitening strips, whitening systems and mouth rinses.

"With the acquisition of REMBRANDT(R), we will continue our tradition of providing innovative oral care solutions to consumers and dental professionals," said Michael Sneed, Johnson & Johnson Consumer Company Group Chairman, North America. "The outstanding REMBRANDT(R) equity joins our existing oral care lineup that includes REACH(R) Toothbrushes, Johnson & Johnson REACH(R) Dental Floss, ACT(R) Rinse and the REACH(R) ACCESS. Daily Flosser."

Personal Products Company, a division of McNeil-PPC, Inc., develops, produces and markets innovative oral health, women's health and sanitary protection products. It is a leader in the fast growing oral health market with a full line of floss, rinse and toothbrush products, marketed under the REACH(R) brand, as well as ARESTIN(R) (minocycline HCl) 1 mg Microspheres, which is a treatment for periodontal disease. Other leading brands of Personal Products Company include MONISTAT(R), K-Y Brand Liquid(R), CAREFREE(R), o.b.(R) and STAYFREE(R).

CONTACT: Media: Iris Grossman, +1-908-874-1838, or Investors: Stan Panasewicz, +1-732-524-2524, both for Personal Products Company

Web site: http://www.jnj.com/

Company News On-Call: http://www.prnewswire.com/comp/467347.html

COPYRIGHT 2005 PR Newswire Association LLC
COPYRIGHT 2005 Gale Group

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