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Argatroban

Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the FDA for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. In 2002, it was approved for use during percutaneous coronary interventions in patients who have or at risk for developing HIT. more...

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Argatroban is given intravenously. Argatroban is metabolized in the liver and has a half life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).

It is manufactured by GlaxoSmithKline.

Reference

  • Di Nisio M, Middeldorp S, Buller HR. Direct thrombin inhibitors. N Engl J Med 2005;353:1028-40. PMID 16148288.

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Mitsubishi Pharma Launches Selective Antithrombin Agent Argatroban in Germany
From JCNN News Summaries, 7/22/05

Tokyo, Japan, July 21, 2005 - (JCNN) - Mitsubishi Pharma (TSE: 4509) announced July 20 that its overseas subsidiary Mitsubishi Pharma Europe of London received approval to market argatroban, Mitsubishi Pharma's proprietary selective antithrombin agent, as of June 1 and put it on sale on July 15.

Mitsubishi Pharma Deutaschland is now marketing the agent under the trade name of Argatra in Germany.

Mitsubishi Pharma Europe plans to introduce the drug in Sweden, Holland, Austria, and Italy upon approval by authorities in respective countries.

Source: JCN http://www.japancorp.net

Copyright [c] 2005 Japan Corporate News Network. All rights reserved.

COPYRIGHT 2005 Japan Corporate News Network K.K.
COPYRIGHT 2005 Gale Group

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