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Augmentin

Co-amoxiclav is the British Approved Name, in the British Pharmacopoeia, for the combination antibiotic containing Amoxicillin (as either trihydate or the sodium salt) and Clavulanic acid (as Potassium clavulanate). This name, unlike co-trimoxazole, has not been widely adopted internationally and the combination product is usually referred to by various names such as amoxicillin with clavulanic acid or amoxicillin+clavulanate or simply by the trade name. more...

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Co-amoxiclav is currently marketed by GlaxoSmithKline under the trade name Augmentin®, and by Pfizer as Clavamox® (Clavamox® is for veterinary use only).

The combination of amoxicillin, a β-lactam antibiotic; with clavulanic acid, a β-lactamase inhibitor; results in an antibiotic with an increased spectrum of action and restored efficacy against β-lactamase producing amoxicillin-resistant bacteria.

Dosage

  • Co-amoxiclav sensitive organisms

Side effects

Amongst the possible side-effects of this medication are diarrhoea, vomiting and a few other conditions. These do not usually require medical attention. However, if the patient experiences an allergic reaction to the medication, jaundice, fever or severe diarrhoea, it is necessary to contact a doctor immediately.

Amoxicillin is a member of the penicillin family of antibiotics, and therefore should not be taken by patients allergic to penicillin.

Read more at Wikipedia.org


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Antibiotics and ear infections - Augmentin - Brief Article
From Pediatrics for Parents, 11/1/03

Doctors, parents, and pharmaceutical companies all like to believe that giving antibiotics to children with ear infections really makes a difference. A recent Finnish study finds that Augmentin (a combination of amoxicillin and clavulanate) does make a difference.

Sixty six children, ages 6-months-to 6-years-old, with tympanostomy tubes (tubes in their ear drums) met the study criteria. Each had pussy fluid (otorrhea) coming through at least one ear tube--an indication of middle ear infection (otitis media) and hadn't been on antibiotics for at least 2 weeks.

Half the children were started on Augmentin while the other half received a placebo that looked and tasted the same as the real medicine. For the following seven days, the children were seen every day. Fluid was suctioned from their infected ear through the ear tube. The fluid was then cultured.

At the end of the seven day period, the otorrhea had gone away in 28 of 34 children (82%) who received the medicine and in 13 of the 32 children (41%) who received the placebo. The middle ear fluid obtained from the children who received the antibiotic contained bacteria for an average of one day, while the fluid from the children who received the placebo contained bacteria for the entire length of the study.

This study shows that for children with ear tubes, otorrhea, and the signs and symptoms of an ear infection, treatment with the antibiotic Augmentin significantly speeds up the resolution of the infection. Unfortunately, there was no further follow-up to see if treatment affected subsequent ear infections.

Pediatrics, 5/03.

COPYRIGHT 2003 Pediatrics for Parents, Inc.
COPYRIGHT 2004 Gale Group

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