Rosiglitazone chemical structure
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Avandia

Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. It is being marketed as Avandia® by the pharmaceutical company GlaxoSmithKline, both as a standalone preparation and in combination with metformin (Avandamet®). Another combination drug approved by the FDA is Avandaryl® (with glimepiride). more...

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Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. Rosiglitazone is a pure ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone (Mohanty et al).

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Avandia hits 1 million retail scripts - Brief Article
From Drug Store News, 2/21/00 by Kim Roller

Avandia, SmithKline Beecham's oral diabetes drug, which was approved last May, has passed the 1 million retail prescription mark in its first seven months on the market and is leading the thiazolidinedione class. That class includes Takeda's Actos and Warner-Lambert's Rezulin. The company said it is seeking expanded indications in 2000 for the drug, which was approved for the treatment of type 2 diabetes as both monotherapy and in combination with metformin as an adjunct to diet and exercise.

COPYRIGHT 2000 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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