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Campath

Alemtuzumab (marketed as Campath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL) and T-cell lymphoma. more...

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Alemtuzumab targets CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It is used as second line therapy for CLL. It was approved by the FDA for patients who have been treated with alkylating agents and who have failed fludarabine therapy.

A significant complication of therapy with alemtuzumab is that it significantly increses the risk for opportunistic infections, in particular, reactivation of cytomegalovirus.

Alemtuzumab is also used in some conditioning regimens for bone marrow transplantation.

History

The origins of alemtuzumab date back to Campath-1 which was derived from the mouse antibodies raised against human lymphocyte proteins (Hale et al 1983). The name "Campath" derives from the pathology department of Cambridge University. Initially, Campath-1 was unsuitable for therapy because patients reacted against the foreign mouse protein of the antibody. To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafted it onto a human antibody framework. This became known as Campath-1H and serves as the basis for alemtuzumab (Riechmann et al 1988).

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Genzyme Corporation to Acquire Ilex Oncology Inc. for 32.82 Times Reveune
From Weekly Corporate Growth Report, 3/8/04

The Deal: Genzyme Corporation has agreed to acquire Ilex Oncology Inc. in a stock transaction valued at over $1 billion. Under the terms of the agreement, each share of Ilex Oncology will be exchanged for $26 of Genzyme stock. The deal is expected to close by the middle of the year.

Discussion: Ilex Oncology is a biotechnology company that performs oncology research and develops drugs for the treatment of bladder cancer, solid tumors, and other forms of cancer. The company's leading drug product, Campath, is used as a treatment for chronic lymphocytic leukemia. The company is also developing a possible treatment for blood cancers and solid tumors. Campath is sold through German pharmaceutical company Schering AG.

Genzyme Corporation operates three main divisions. Genzyme General provides drug development, genetic testing and other services. Genzyme Molecular Oncology develops gene-based cancer diagnosis and treatment products.

Genzyme Biosurgery manufactures orthopedic medical and surgical products.

The acquisition will expand Genzyme's oncology division. Genzyme's cancer-research program costs about $20 million a year. The program's nearest-term prospect, a kidney-cancer vaccine, is at least four years away from market approval. Ilex, however, has immediate and near-term oncology products. Sales of Campath reached $71.7 million last year, an increase of 63 percent from sales in 2002.

Copyright NVST, Inc. Mar 8, 2004
Provided by ProQuest Information and Learning Company. All rights Reserved

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