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Campath

Alemtuzumab (marketed as Campath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL) and T-cell lymphoma. more...

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Alemtuzumab targets CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It is used as second line therapy for CLL. It was approved by the FDA for patients who have been treated with alkylating agents and who have failed fludarabine therapy.

A significant complication of therapy with alemtuzumab is that it significantly increses the risk for opportunistic infections, in particular, reactivation of cytomegalovirus.

Alemtuzumab is also used in some conditioning regimens for bone marrow transplantation.

History

The origins of alemtuzumab date back to Campath-1 which was derived from the mouse antibodies raised against human lymphocyte proteins (Hale et al 1983). The name "Campath" derives from the pathology department of Cambridge University. Initially, Campath-1 was unsuitable for therapy because patients reacted against the foreign mouse protein of the antibody. To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafted it onto a human antibody framework. This became known as Campath-1H and serves as the basis for alemtuzumab (Riechmann et al 1988).

Read more at Wikipedia.org


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Chronic Lymphocytic Leukemia - CLL - Patients Reach Five-Year Survival Milestone After Receiving Campath Therapy
From Business Wire, 5/25/05

Chronic Lymphocytic Leukemia (CLL) is the most prevalent form of adult leukemia. According to a recent study, 84 percent of patients with CLL in whom all detectable traces of the disease were eliminated were still alive at least five years after receiving Campath (alemtuzumab) therapy. The study was published in the May issue of the Journal of Clinical Oncology and represents a major step towards finding a cure for CLL.

You can reach the story directly by going to http://www.newstream.com/home.aspx?story=30513

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COPYRIGHT 2005 Business Wire
COPYRIGHT 2005 Gale Group

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