When normal cells are damaged beyond repair, they are eliminated by apoptosis.  Cancer cells avoid apoptosis and continue to multiply in an unregulated manner.Cancers are caused by a series of mutations.  Each mutation alters the behavior of the cell somewhat.Tissue can be organized in a continuous spectrum from normal to cancer.The incidence of lung cancer is highly correlated with smoking. Source:NIH.
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Cancer

Cancer is a class of diseases characterized by uncontrolled division of cells and the ability of these cells to invade other tissues, either by direct growth into adjacent tissue (invasion) or by implantation into distant sites (metastasis). This unregulated growth is caused by damage to DNA, resulting in mutations to genes that control cell division. Several mutations may be required to transform a normal cell into a malignant cell. These mutations are often caused by chemicals or physical agents called carcinogens. Some mutations occur spontaneously, or they can be inherited (germ line mutations.) more...

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Cancer can cause many different symptoms, depending on the site and character of the malignancy and whether there is metastasis. Cancer may be painless. A definitive diagnosis usually requires the histologic examination of tissue by a pathologist. This tissue is obtained by biopsy or surgery. Once diagnosed, cancer is usually treated with surgery, chemotherapy, or radiation.

If untreated, cancers may eventually cause death. Cancer is mainly a disease of later years, and is one of the leading causes of death in developed countries. Most cancers can be treated and many cured, especially if treatment begins early. Many forms of cancer are associated with exposure to environmental factors, such as tobacco smoking, alcohol, and certain viruses. Some of these can be avoidable, and public health and vaccination programmes are important on a global scale.

History

Hippocrates described several kinds of cancers. He called benign tumours oncos, Greek for swelling, and malignant tumours carcinos, Greek for crab or crayfish. This strange choice of name probably comes from the appearance of the cut surface of a solid malignant tumour, with a roundish hard center surrounded by pointy projections, vaguely resembling the silhouette of a crab. He later added the suffix -oma, Greek for swelling, giving the name carcinoma. Today, carcinoma is the medical term for a malignant tumour derived from epithelial cells. It is Celsus who translated carcinos into the latin cancer, also meaning crab. Galen used "oncos" to describe all tumours, the root for the modern word oncology.

Classification and nomenclature

Cancers are classified by the type of cell that resembles the tumor and, therefore, the tissue presumed to be the origin of the tumor. The following general categories are usually accepted:

  • Carcinoma: malignant tumors derived from epithelial cells. This group represent the most common cancers, including the common forms of breast, prostate, lung and colon cancer.
  • Lymphoma and Leukemia: malignant tumors derived from blood and bone marrow cells
  • Sarcoma: malignant tumors derived from connective tissue, or mesenchymal cells
  • Mesothelioma: tumors derived from the mesothelial cells lining the peritoneum and the pleura.
  • Glioma: tumors derived from brain cells
  • germ cell tumours: tumors derived from germ cells, normally found in the testicle and ovary
  • Choriocarcinoma: malignant tumors derived from the placenta

Malignant tumors are usually named using the Latin or Greek root of the organ as a prefix and the above category name as the suffix. For instance, a malignant tumor of liver cells is called hepatocarcinoma; a malignant tumor of the fat cells is called liposarcoma. For common cancers, the English organ name is used. For instance, the most common type of breast cancer is called ductal carcinoma of the breast or mammary ductal carcinoma. Here, the adjective ductal refers to the appearance of the cancer under the microscope, resembling normal breast ducts.

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Breast cancer
From Ebony, 10/1/05

For about a year, Denise Roberts noticed something was wrong with her body. "I was fatigued, I had dark circles appearing under my eyes that couldn't be covered with makeup and my hair was coming out in handfuls," says the California resident. Her grandmother had died of breast-cancer after having a mastectomy; her brother died from leukemia and her aunt was a 17-year breast-cancer survivor.

She decided to get a mammogram. Doctors noticed an abnormality and did a biopsy, but later told her everything was fine. Roberts' husband, an orthopedic surgeon, was worried and decided to get a second opinion. "That second opinion literally saved my life," says Roberts, founder and president of The Denise Roberts Breast Cancer Foundation.

The results showed that Roberts did indeed have breast cancer in her right breast. Today, she's an 18-year breast-cancer survivor.

For many women, just hearing the words "breast cancer" evokes strong emotions--mainly fear. More than 19,000 new cases of breast cancer are expected to occur among African-American women this year, according to the American Cancer Society. Breast cancer is the second most common cause of cancer-related death among Black women, surpassed only by lung cancer, according to the American Cancer Society. Studies suggest that Black women die at a greater rate because oftentimes detection occurs later when tumors are in more advanced stages, thus limiting treatment options.

Doctors say the key to battling breast cancer is early detection. Experts recommend that women 40 years and older get a mammogram and have a clinical breast examination once a year. Women between ages 20-39 are encouraged to conduct breast self-exams as well as get a clinical breast examination every three years. Younger Black women need to be particularly aware of the disease, says Roberts. The incidence of breast cancer among Black women under 40 is higher than that of White women, according to the American Cancer Society. "We are fighting every day in this foundation to get the rules changed about taking care of women under the age of 40," says Roberts. "There are all kinds of programs that will pay for Sisters, 40 and over, who don't have insurance, but there are maybe one or two [for Black women under 40]."

One group of researchers from the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center looked at the link between ethnicity and breast cancer and found that one reason the mortality rate is so high is because of the differences in risk factors and biological makeup in Black women. The researchers discovered that more White women tend to get breast cancer because they are more likely to drink alcohol or use hormone-replacement therapy, both which increase a woman's risk of developing the disease. Researchers also examined tumor characteristics and discovered that it was more common for Black women to have high-grade aggressive tumors and tumors without estrogen receptors. Those types of tumors are more difficult to treat. African-American women also tend to have different mutations in the BRCA1 and BRCA2 genes (short for breast cancer 1 and breast cancer 2). Both genes work to suppress tumors, but when there is a mutation, the genes don't properly suppress cancer or abnormal growth.

In another study, researchers at Columbia University have discovered that substantial weight gain, especially after age 50 can increase a woman's risk of developing breast cancer. The study looked at nearly 2,000 women, some with and some without breast cancer, and women age 50 and older who gained 25 pounds or more were 62 percent more likely to develop breast cancer. The study also showed that women over the age of 20 who gained more than 33 pounds had a 60 percent greater risk of developing breast cancer, compared to women over 20 who maintained a stable weight.

According to the researchers, there is a link between breast cancer and weight because excess body fat may elevate estrogen levels. It is believed that both estrogen and progesterone can fuel the growth of some breast tumors.

While simply thinking about breast cancer may be frightening, Black women, both young and older, should continue to educate themselves about the disease, advises Roberts. "We're still looked upon as women of color, and we're not a priority unless we make ourselves a priority," she says. "What every Sister has to understand if those words come back 'you have breast cancer' is don't go in the space of 'I'm going to die.' Go into that space of 'I've got to fight, and let me find people that will help me.'"

COPYRIGHT 2005 Johnson Publishing Co.
COPYRIGHT 2005 Gale Group

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