Carisoprodol chemical structure
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Carisoprodol

Carisoprodol is a skeletal muscle relaxant whose active metabolite is meprobamate. Although several case reports have shown that carisoprodol has abuse potential, it continues to be widely prescribed (not so in the United Kingdom where use of benzodiazepines is preferred). Carisoprodol is a colorless, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water and freely soluble in alcohol, chloroform and acetone. Its solubility is practically independent of pH. more...

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It is marketed in the United States under the brand name Soma, and in the United Kingdom and other countries under the brand name Carisoma.

Chemistry

It is a carbamic acid ester. Carisoprodol is a racemic mixture of two stereoisomers.

Effects

→ Somnolence

→ Ataxia

→ Anterograde amnesia

Pharmacokinetics

Carisoprodol has a rapid onset of action, with the aforementioned effects lasting for approximately 2-4 hours.

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Correction
From American Family Physician, 11/1/04

The Letter to the Editor, "Tolerance and Dependence Risk with the Use of Carisoprodol," by Craig Heacock, M.D., and Mark S. Bauer, M.D. (April 1, 2004, page 1622), incorrectly stated that meprobamate is a schedule IV barbiturate with a long history of abuse. The second sentence in the first paragraph of the letter should have stated that meprobamate is a schedule IV drug that has a long history of abuse and exhibits cross-tolerance to barbiturates. Meprobamate is a bis-carbamate ester and is not a member of the barbiturate family. The online version of this letter has been corrected.

COPYRIGHT 2004 American Academy of Family Physicians
COPYRIGHT 2004 Gale Group

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