Castleman's disease is a rare disease of the lymphatic system. It involves hypeproliferation of certain B cells that often produce cytokines. There are several variants of this disease. One called multicentric Castleman's disease (MCD) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus that is also the cause of Kaposi's sarcoma and primary effusion lymphoma. MCD most commonly develops in immunosuppressed patients such as those with AIDS. The most striking clinical features of MCD are high fevers, anemia, and low white blood cell counts, which appear to be due to the overproduction of interleukin 6. more...
There is no standard therapy for Castleman's disease; MCD carries a poor prognosis of about 2 years.
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