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Cerebral palsy

Cerebral palsy or CP is a group of permanent disorders associated with developmental brain injuries that occur during fetal development, birth, or shortly after birth. It is characterized by a disruption of motor skills, with symptoms such as spasticity, paralysis, or seizures. Cerebral palsy is a form of static encephalopathy. The incidence is about 1.5 to 4 per 1000 live births. One form of it, spastic diplegia, is sometimes known as Little's disease in the United Kingdom. Properly speaking, the fact that CP does not get better or worse implies that it is a 'condition' (chronic nonprogressive neurological disorder) rather than a 'disease'. more...

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There is no cure, but therapy and Conductive Education has been shown to be helpful. Conversely, gait and posture can get worse over time if left untreated. While severity varies widely, cerebral palsy ranks among the most costly congenital conditions to manage.

Cerebral palsy has been described as something of an "umbrella term" in that it refers to a group of different conditions. It has been suggested that no two people with CP will have an identical case even if they have the same diagnosis.

Cerebral palsy develops while the brain is under development. 80% of all cases occur before the baby reaches 1 month old, however this disorder can occur within about the first 5 years of life. It is a nonprogressive disorder; once damage to the brain occurs, no additional damage occurs as a result of this condition. Cerebral palsy neither improves nor worsens, though symptoms may seem to increase with time, likely due to the aging process.

History

Cerebral palsy, then known as "Cerebral Paralysis", was first identified by a British surgeon named William Little in 1860. Little raised the possibility of asphyxia during birth as a chief cause of the disorder. It was not until 1897 that Sigmund Freud suggested that a difficult birth was not the cause but rather only a symptom of other effects on fetal development. Modern research has shown that asphyxia is not found during birth in at least 75% of cases. Such research also shows that Freud's view was correct, even though during the late 19th century and most of the 20th century Little's view was the traditional explanation. ("Conditions", 9)

Cause

Since cerebral palsy refers to a group of disorders, there is no exact known cause. Some major causes are asphyxia, hypoxia of the brain, birth trauma or premature birth, genetic susceptibility, certain infections in the mother during and before birth, central nervous system infections, trauma, and consecutive hematomas. In most people with CP, the cause is unknown. After birth, the condition may be caused by toxins, physical brain injury, incidents involving hypoxia to the brain (such as drowning), and encephalitis or meningitis. Despite all of these causes, the cause of many individual cases of cerebral palsy is unknown.

Recent research has demonstrated that asphyxia is not the most important cause as it was once considered to be, though it still plays a role, probably accounting for about 10 percent of all cases. The research has shown that infections in the mother, even infections that are not easily detected, may triple the risk of the child developing the disorder.

Premature babies have a higher risk because their organs are not yet fully developed. This increases the risk of asphyxia and other injury to the brain, which in turn increases the incidence of cerebral palsy.

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Determination of body composition in children with cerebral palsy
From Nutrition Research Newsletter, 6/1/05

Recent population-based studies, have shown that 30% to 40% of children with cerebral palsy (CP) have been assessed to be undernourished. Clinicians and researchers are hampered by the complexities of evaluating nutritional status in children with CP.

Height is an unreliable measure and children with CP have an altered body composition, with fat mass maintained more centrally as compared with able-bodied peers. DEXA is one method for assessing these nutritional compartments, while bioelectrical impedance (BIA) is a less-expensive and more portable method. A recent study published in JADA set out to determine whether BIA and DEXA can be used to determine body composition for clinical and research purposes in children with CP.

Eight children with cerebral palsy (2 female, 8 male) were recruited from an outpatient tertiary care setting. The children underwent measurement of FM, FFM, and percentage body fat using BIA, anthropometry (two and four skinfold equations), and DEXA. Correlation coefficients were calculated for FM, FFM, and percent body fat for these measures as determined by BIA, and anthropometry when compared with DEXA.

Correlation coefficients were excellent for determination of FFM for all methods (that is, all were above 0.9). Correlations were moderate for determination of FM and percent body fat (0.4 to 0.8). BIA performed best for determining FM and skinfold equations were best for determining percent body fat. For all assessments, there was no advantage in using anthropometric equations that factor in four skinfold measures over those that factor in only two skinfold measures.

The results are consistent with those of previous researchers aM confirm the high correlation of BIA with DEXA for determination of FFM. Because of the clinical trial they were in, the children in this study had been fasting for a period of time before BIA measurements. This may have affected results because assessment is dependent on total body water. The study is also limited because of the small numbers evaluated. Therefore, these data support the need for a larger trial to investigate these methods further.

Li-Fen Liu, Ryan Roberts, Laurie Moyer-Mileur, and Lisa Samson-Fang, Determination of Body Composition in Children with Cerebral Palsy: Bioelectrical Impedance Analysis and Anthropometry vs Dual-Energy X-Ray Absorptiometry. JADA; 105:794-797 (May, 2005). [Correspondence: Lisa Samson-Fang, MD, Department of Pediatrics, University of Utah School of Medicine, 50 North Medical Dr, Salt Lake City, UT 84132. E-mail: Lisa.SamsonFang@HSC.Utah.EDU]

COPYRIGHT 2005 Frost & Sullivan
COPYRIGHT 2005 Gale Group

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