Baycol LogoChemical structure of cerivastatin
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Cerivastatin

In pharmacology, cerivastatin (Baycol®, Lipobay®) is a synthetic member of the class of statins, used to lower cholesterol and prevent cardiovascular disease. It was withdrawn from the market in 2001 because of the high rate of serious side-effects. more...

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Cerivastatin was marketed by the pharmaceutical company Bayer A.G. in the late 1990s as a new synthetic statin, to compete with Pfizer's highly successful Lipitor®.

During post-marketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant renal failure. Risks were higher in patients using fibrates (mainly gemfibrozil/Lopid®) and in patients using the high (0.8 mg/day) dose of cerivastatin. Another 385 nonfatal cases of rhabdomyolysis were reported. This put the risk of this (rare) complication at 5-10 times that of the other statins.

In 2001, Bayer announced the voluntary withdrawal of the drug from the market.

Important Note

On August 8, 2001 the U.S. Food and Drug Administration FDA announced that Bayer Pharmaceutical Division is voluntarily withdrawing Baycol (cerivastatin) from the U.S. market because of reports of sometimes fatal rhabdomyolysis, a severe muscle adverse reaction from this cholesterol-lowering (lipid-lowering) product . The FDA agrees with and supports this decision. All patients taking Baycol should contact their healthcare providers to discuss treatment alternatives.

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Reduced risk of glaucoma with statins
From Geriatrics, 9/1/04

Source: McGwin G Jr, McNeal S, Owsley C, Girkin C, Epstein D, Lee PP. Statins and other cholesterol-lowering medications and the presence of glaucoma. Arch Ophthalmol 2004; 122(6):822-6. Long-term use of statins may yield a reduced risk of open-angle glaucoma in those with cardiovascular (CV) and lipid diseases. Researchers assessed the medical records of 667 men age >50 diagnosed with glaucoma at the Veterans Affairs Medical Center in Birmingham, Ala., between 1997 and 2001. Of these, 170 were diagnosed with open-angle glaucoma, 31 had specified forms of glaucoma, and 466 had unspecified glaucoma. Each case was age-matched with 10 controls without glaucoma (n=6,667).

Researchers tracked prescriptions for statins (atorvastatin, cerivastatin, fluvastatin, pravastatin, simvastatin, lovastatin) and nonstatin lipid-lowering agents, including fibrates and nicotinic acid. Using ICD-9-CM, they coded for ischemic heart disease; cerebrovascular disease; lipid metabolism disorders; hypertension; diseases of the arteries, arterioles, and capillaries; and diabetes.

There was a significant trend toward reduced risk of glaucoma with longer-term statin use (p=0.04). Use of nonstatin lipid-lowering therapy also was associated with a significantly reduced glaucoma risk among current and past users. Concurrent use of statin and nonstatin medications resulted in the largest risk reduction (OR, 0.52), followed by nonstatin use only (OR 0.60), and statin use only (OR, 0.60).

Significant associations existed between statin use and glaucoma among those with lipid metabolism disorders, cardiovascular disease, and those without cerebrovascular disease.

COPYRIGHT 2004 Advanstar Communications, Inc.
COPYRIGHT 2005 Gale Group

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