Find information on thousands of medical conditions and prescription drugs.

Cervical cancer

Cervical cancer is a malignancy of the cervix. Worldwide, it is the second most common cancer of women. It may present with vaginal bleeding but symptoms may be absent until the cancer is in advanced stages, which has made cervical cancer the focus of intense screening efforts utilizing the Pap smear. Most scientific studies point to human papillomavirus (HPV) infection as a necessary pre-requisite for development of cervical cancer. Treatment is with surgery (including cryosurgery) in early stages and chemotherapy and radiotherapy in advanced stages of the disease. An effective vaccine for the two most common strains of HPV has recently been licenced (see below). more...

Home
Diseases
A
B
C
Angioedema
C syndrome
Cacophobia
Café au lait spot
Calcinosis cutis
Calculi
Campylobacter
Canavan leukodystrophy
Cancer
Candidiasis
Canga's bead symptom
Canine distemper
Carcinoid syndrome
Carcinoma, squamous cell
Carcinophobia
Cardiac arrest
Cardiofaciocutaneous...
Cardiomyopathy
Cardiophobia
Cardiospasm
Carnitine transporter...
Carnitine-acylcarnitine...
Caroli disease
Carotenemia
Carpal tunnel syndrome
Carpenter syndrome
Cartilage-hair hypoplasia
Castleman's disease
Cat-scratch disease
CATCH 22 syndrome
Causalgia
Cayler syndrome
CCHS
CDG syndrome
CDG syndrome type 1A
Celiac sprue
Cenani Lenz syndactylism
Ceramidase deficiency
Cerebellar ataxia
Cerebellar hypoplasia
Cerebral amyloid angiopathy
Cerebral aneurysm
Cerebral cavernous...
Cerebral gigantism
Cerebral palsy
Cerebral thrombosis
Ceroid lipofuscinois,...
Cervical cancer
Chagas disease
Chalazion
Chancroid
Charcot disease
Charcot-Marie-Tooth disease
CHARGE Association
Chediak-Higashi syndrome
Chemodectoma
Cherubism
Chickenpox
Chikungunya
Childhood disintegrative...
Chionophobia
Chlamydia
Chlamydia trachomatis
Cholangiocarcinoma
Cholecystitis
Cholelithiasis
Cholera
Cholestasis
Cholesterol pneumonia
Chondrocalcinosis
Chondrodystrophy
Chondromalacia
Chondrosarcoma
Chorea (disease)
Chorea acanthocytosis
Choriocarcinoma
Chorioretinitis
Choroid plexus cyst
Christmas disease
Chromhidrosis
Chromophobia
Chromosome 15q, partial...
Chromosome 15q, trisomy
Chromosome 22,...
Chronic fatigue immune...
Chronic fatigue syndrome
Chronic granulomatous...
Chronic lymphocytic leukemia
Chronic myelogenous leukemia
Chronic obstructive...
Chronic renal failure
Churg-Strauss syndrome
Ciguatera fish poisoning
Cinchonism
Citrullinemia
Cleft lip
Cleft palate
Climacophobia
Clinophobia
Cloacal exstrophy
Clubfoot
Cluster headache
Coccidioidomycosis
Cockayne's syndrome
Coffin-Lowry syndrome
Colitis
Color blindness
Colorado tick fever
Combined hyperlipidemia,...
Common cold
Common variable...
Compartment syndrome
Conductive hearing loss
Condyloma
Condyloma acuminatum
Cone dystrophy
Congenital adrenal...
Congenital afibrinogenemia
Congenital diaphragmatic...
Congenital erythropoietic...
Congenital facial diplegia
Congenital hypothyroidism
Congenital ichthyosis
Congenital syphilis
Congenital toxoplasmosis
Congestive heart disease
Conjunctivitis
Conn's syndrome
Constitutional growth delay
Conversion disorder
Coprophobia
Coproporhyria
Cor pulmonale
Cor triatriatum
Cornelia de Lange syndrome
Coronary heart disease
Cortical dysplasia
Corticobasal degeneration
Costello syndrome
Costochondritis
Cowpox
Craniodiaphyseal dysplasia
Craniofacial dysostosis
Craniostenosis
Craniosynostosis
CREST syndrome
Cretinism
Creutzfeldt-Jakob disease
Cri du chat
Cri du chat
Crohn's disease
Croup
Crouzon syndrome
Crouzonodermoskeletal...
Crow-Fukase syndrome
Cryoglobulinemia
Cryophobia
Cryptococcosis
Crystallophobia
Cushing's syndrome
Cutaneous larva migrans
Cutis verticis gyrata
Cyclic neutropenia
Cyclic vomiting syndrome
Cystic fibrosis
Cystinosis
Cystinuria
Cytomegalovirus
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Restrictive cardiomyopathy
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

Signs and symptoms

The early stages of cervical cancer may be completely asymptomatic (Canavan & Doshi, 2000). Vaginal bleeding, contact bleeding or (rarely) a vaginal mass may indicate the presence of malignancy. In advanced disease, metastases may be present in the abdomen, lungs or elsewhere.

The possibility to identify premalignant changes on a cervical smear has made screening the major cause for referral of women with possible cervical neoplasia. In many countries, women are advised to have a regular Pap smear to check for premalignant changes. Recommendations for how often a Pap smear should be done vary from once a year to once every five years. If cervical cancer is detected early, it can be treated without impairing fertility. Consistently abnormal smears may be a reason for further diagnosis despite complete absence of symptoms.

Diagnosis

Diagnosis is made by doing a biopsy of the cervix, which often involves colposcopy, or a magnified visual inspection of the cervix aided by using an acetic acid solution to produce color changes in precancerous or cancerous areas. A Pap smear is insufficient for the diagnosis. Many researchers recommend that since more than 99% of invasive cervical cancers worldwide contain human papillomavirus, HPV testing should be carried out together with routine cervical screening (Walboomers et al, 1999). However, given the prevalence of HPV (around 80% infection history among the sexually active population) others suggest that routine HPV testing would cause undue alarm to carriers.

Further diagnostic procedures are loop electrical excision procedure (LEEP) and conisation, in which the inner lining of the cervix is removed to be examined pathologically. These are carried out if the biopsy confirms severe dysplasia.

Histology

Types of malignant cervical tumors include the following:

  • M8070/3: squamous cell carcinoma (about 80-85%)
  • M8140/3: adenocarcinoma
  • M8560/3: adenosquamous carcinomas
  • M8041/3: small cell carcinoma
  • M8246/3: neuroendocrine carcinoma
  • M8720/3: melanoma
  • (varied): lymphoma

Staging

Cervical cancer is staged by the FIGO staging system, which is based on clinical examination, rather than surgical findings. It allows only the following diagnostic tests to be used in determining the stage: palpation, inspection, colposcopy, endocervical curettage, hysteroscopy, cystoscopy, proctoscopy, intravenous urography, and X-ray examination of the lungs and skeleton, and cervical conization.

The TNM staging system for cervical cancer is analogous to the FIGO stage.

  • Stage 0 - full-thickness involvement of the epithelium without invasion into the stroma (carcinoma in situ)
  • Stage I - limited to the uterus
    • IA - diagnosed only by microscopy; no visible lesions
      • IA1 - stromal invasion less than 3 mm in depth and 7 mm or less in horizontal spread
      • IA2 - stromal invasion between 3 and 5 mm with horizontal spread of 7 mm or less
    • IB - visible lesion or a microscopic lesion with more than 5 mm of depth or horizontal spread of more than 7 mm
      • IB1 - visible lesion 4 cm or less in greatest dimension
      • IB2 - visible lesion more than 4 cm
  • Stage II - invades beyond uterus
    • IIA - without parametrial invasion
    • IIB - with parametrial invasion
  • Stage III - extends to pelvic wall or lower 1/3 of the vagina
    • IIIA - involves lower 1/3 of vagina
    • IIIB - extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney
  • IVA - invades mucosa of bladder or rectum and/or extends beyond true pelvis
  • IVB - distant metastasis

Note that the FIGO stage does not incorporate lymph node involvement in contrast to the TNM staging for most other cancers.

Read more at Wikipedia.org


[List your site here Free!]


Why annual Pap tests matter: less stringent cervical-cancer screening guidelines could put your health at risk - health
From Essence, 6/1/03 by Judith Springer Riddle

Tamika L. Felder was an ambitious freelance television producer in Washington, D.C. She maintained a healthy diet and was diligent about getting medical checkups, including a yearly Pap test to screen for cervical cancer. Because her test results were always normal, Felder began to take them, and her gynecological health, for granted. So when a job change left Felder temporarily without health insurance, she was unconcerned. "I knew I needed to go to the gynecologist, but since I wasn't sexually active at the time, I thought I could let it slide for a while," she says.

But Felder's "temporary" insurance lapse stretched to two years without a medical checkup. When she finally saw a gynecologist for a routine exam and Pap test, she was diagnosed with an aggressive form of cervical cancer. A week before her twenty-sixth birthday, Felder had to undergo a radical hysterectomy.

THE PAP TEST CONTROVERSY

Cervical cancer is one of the most curable forms of cancer. In fact, for the general population, the five-year survival rate for the disease is 71 percent. But African-American women are more than twice as likely to die of cervical cancer as White women because far too many of us, for various reasons, don't get regular Pap tests. That's why some question the recent decision by the American Cancer Society (ACS) to relax their guidelines for how often women should get cervical-cancer screening. In effect, these new recommendations could prove to be deadly for Black women.

These new guidelines suggest that women age 30 or older who have had three consecutive normal Pap results be screened only every two to three years, and that Pap tests be done annually only if the traditional Pap evaluation method is used. If a newer, more accurate liquid-based test is used, the ACS suggests a woman be screened only every two years. Ironically, Felder fell into the latter category, because her previous tests had been normal. Yet waiting two years nearly claimed her life.

The ACS says the new guidelines were developed, in part, to reduce the number of unnecessary procedures performed on women with abnormal but inconclusive Pap results. But some doctors worry that the revised policy will cause women, particularly African-Americans, to put off getting tested--which could have alarming consequences. "The danger with the new guidelines is that they appear to be more lenient about cervical-cancer screening," warns Robert Bristow, M.D., a gynecologist-oncologist and assistant professor at Johns Hopkins Medical Institutions in Baltimore. "Women who should be getting a Pap smear every two to three years may think they're no longer that important and delay being tested for five or seven years."

Hilda Hutcherson, M.D., an ESSENCE columnist and assistant professor of OB-GYN at Columbia Presbyterian Medical Center in New York City, goes a step further and rejects the new guidelines outright. "I continue to tell women to get cervical-cancer screening every year," Hutcherson says.

Proponents of the new guidelines say that they are just that--guidelines--not hard-and-fast rules. "Doctors should assess each patient individually as to how often she needs a Pap smear based on her cervical-cancer risk, age, medical history, number of sexual partners and the screening tests used," says Paula Hillard, M.D., a gynecologist who served on the ACS task force that developed the guidelines.

Today, at age 28 and cancer-free, Tamika Felder has devoted herself to educating women about cervical cancer through lectures and a self-published E-newsletter. Not surprisingly, Felder also thinks women should have yearly Pap tests. "I always wanted to have a huge family," Felder says. "Now all I can do is wonder if having a Pap test earlier could have saved my chance to have kids."

Making Sense of Pap results

Doctors use these terms to describe cervical-cancer-screening results:

Negative There are no signs of cancer, precancerous changes or other significant abnormalities present.

ASC Atypical squamous cells. This reading indicates that abnormal cells are present but are not precancerous. Your doctor will run a test for human papillomavirus (HPV) and, depending on previous Pap results and the presence of other risk factors, perform a cone biopsy (the removal of a cone-shaped tissue sample from the cervix) or a colposcopy (the examination of the vagina and cervix through a lighted microscope).

SIL Low-grade, high-grade squamous intraepithelial lesion. Often called dysplasia, a low-grade SIL shows an early precursor to cervical cancer that frequently goes away without treatment. A high-grade SIL diagnosis, which suggests the presence of a high-grade cervical precancer, requires treatment to prevent cancer from developing. Your doctor will do a colposcopy following this result.

AGC Atypical glandular cells. This is an abnormality that may be associated with precancers or adenocarcinoma (a malignant tumor originating in glandular tissue). Your doctor will probably recommend a colposcopy.

THE CERVICAL CANCER 'BUG'

Human papillomavirus (HPV) is one of the most common sexually transmitted diseases in the United States. An estimated 5.5 million new cases occur each year in this country, and approximately 20 million Americans are currently infected, according to the Centers for Disease Control and Prevention. Unlike many other STDs, this virus does not need to be in bodily fluids to be transmitted--it can be passed through skin-to-skin contact, so condoms offer little protection. HPV can cause genital warts, flesh-colored growths that can appear on the vulva, in and around the vagina, cervix and anus, or on the penis, scrotum and around the anus in men. In addition, the virus can go away on its own, or stay with you indefinitely and pass unnoticed from person to person. More alarming, doctors now know that certain types of HPV cause more than 90 percent of all cervical cancers, though the mechanism is unclear. Yet many women are unaware of the link between HPV and cervical cancer. In one national survey, 70 percent of women didn't know what caused cervical cancer, and 76 percent had never heard of the virus.

HPV Test

A test for the human papillomavirus (HPV) was recently approved for widespread use by the Food and Drug Administration (FDA). The test can identify 13 strains of HPV that are responsible for most cervical cancers.

Q Who should get the HPV test?

A The FDA recommends the test for women over age 30. While teenagers and women in their 20s are more likely to get HPV because they tend to have more sexual partners, the virus usually clears up on its own. But this is less likely to happen for women over 30.

Q How often should I be tested?

A Women who opt to be tested should have it done every three years and at the same time as the Pap test.

Q What does a positive result mean?

A It means you've been exposed to HPV, but it doesn't automatically mean that you have cancer. Debbie Saslow of the American Cancer Society (ACS) says HPV is very common. In fact, ACS projects that three of every four people will get an HPV infection during their lifetime. Only relatively few strains of the virus can lead to cervical cancer; it's the persistent ones that cause concern. Testing positive once isn't necessarily alarming, says Saslow. "But testing positive two or three times in a row means a somewhat increased risk of cervical changes that have the potential to become cancer down the road."

Q Should I still get a Pap test too?

A Yes. The HPV test is not designed to take the place of the Pap test, but rather to be used in combination with it.

Q Is there any danger if women in their 20s get tested?

A There is potential for harm, says Kenneth Noller, M.D., chairman of the OB-GYN department at the Tuffs-New England Medical Center in Boston. Frequent testing of younger women could lead doctors to prescribe unnecessary treatments that could cause scarring or infertility later on.--Nicole Saunders

PROTECT YOURSELF

Researchers are developing an HPV vaccine. While early results have been encouraging, it will be at least another five to seven years before it will hit the market. Until then, here's what you can do to protect yourself:

PRACTICE ABSTINENCE.

STAY MONOGAMOUS. If abstinence is not an option for you, have sex with only one partner who has sex with only you.

DON'T RELY ON CONDOMS. HPV is spread by direct skin-to-skin contact during vaginal, oral and anal sex, and condoms don't cover all genital skin. And forget over-the-counter protection. Spermicidal foams, creams, and jellies won't protect against HPV and genital warts.

BUTT OUT. Studies have shown that women who smoke are at increased risk of developing dysplasia (a precancerous condition) or full-blown cervical cancer if they have a "high-risk" HPV strain.

Exam SCHEDULE

Grab your calendar and call your doctor. Now that you know how important it is to make sure you get Pap tests regularly, you may be wondering how often and when you should have crucial medical tests. The American Medical Women's Association suggests this schedule:

What exactly is a Pap test?

During a Pap exam a sample of cells and mucus is scraped from the cervix using a cotton swab or a small brush. The sample is then prepared in one of two methods.

1 In the regular Pap test the sample is smeared onto a glass microscope slide, which is then sent to a laboratory for examination by a technician.

2 For the newer liquid-based Pap test, the cells are first placed in a solution and filtered before being mounted on a slide. This liquid-based technique is believed to be more accurate than the traditional test.

TO FURTHER IMPROVE THE ACCURACY OF YOUR EXAM, CONSIDER THE FOLLOWING TIPS:

Don't get a Pap smear while you're having your period.

Do take the test in the middle of your menstrual cycle--the eight to 21 days after your period begins.

Don't douche; have sex; use tampons, birth-control foams, jellies or vaginal creams for two days before the test.

In "Why Pap Tests Matter" (page 83), JUDITH SPRINGER RIDDLE examines the controversy behind the American Cancer Society's new guidelines for cervical-cancer screening. "While the experts I spoke with make a strong case for the revisions made to the original cervical-cancer-screening guidelines, I remain somewhat leery of the new recommendations," she says. Riddle has written for such publications as Heart & Soul and HealthQuest.

COPYRIGHT 2003 Essence Communications, Inc.
COPYRIGHT 2003 Gale Group

Return to Cervical cancer
Home Contact Resources Exchange Links ebay