Cetirizine chemical structureChemical structure of cetirizine
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Cetirizine

Cetirizine hydrochloride is a medication used for the treatment of allergies, hay fever, angioedema, and hives. It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors. It is a major metabolite of hydroxyzine, and has the same basic side effects, including dry mouth. more...

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  • It has long duration of action
  • No reported cardiac toxicity associated with the use of this drug
  • Minimal penetration of the blood-brain barrier
  • Only mild sedating effects, although more than some other non-sedating antihistamines

The medication is produced by UCB, a Belgian pharmaceutical company. The drug is marketed under the following brand names: Zyrtec® in the USA, Zirtek® in the United Kingdom, Zyrlex® in many other European countries, Reactine® in Canada (all by Pfizer ), and as Virlix® in Mexico and parts of Europe (by GlaxoSmithKline ). It can be found under a variety of other brand names in other countries .

Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine hydrochloride, a decongestant. These combinations are marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D®, Virlix-D®, etc.)

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Chewable Cetirizine for Allergy Relief
From Nurse Practitioner, 6/1/04

Pfizer and UCB Pharma have received FDA approval of chewable cetirizine (Zyrtec) for the treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria in children aged 2 years and older.

The chewable formulation of cetirizine offers 24-hour symptom relief and will be available in 5 mg and 10 mg doses in a grape-flavored tablet. It can be taken with or without food or water.

Cetirizine chewable tablets are bioequivalent to cetirizine tablets and offer the same efficacy as cetirizine tablets and syrup.

Most side effects associated with cetirizine are mild or moderate. In infants, side effects associated with cetirizine are similar to placebo and include crankiness, fussiness, and insomnia. Side effects in children aged 2 to 11 years include drowsiness, headache, sore throat, and stomach ache.

Copyright Springhouse Corporation Jun 2004
Provided by ProQuest Information and Learning Company. All rights Reserved

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