Cetirizine chemical structureChemical structure of cetirizine
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Cetirizine

Cetirizine hydrochloride is a medication used for the treatment of allergies, hay fever, angioedema, and hives. It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors. It is a major metabolite of hydroxyzine, and has the same basic side effects, including dry mouth. more...

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  • It has long duration of action
  • No reported cardiac toxicity associated with the use of this drug
  • Minimal penetration of the blood-brain barrier
  • Only mild sedating effects, although more than some other non-sedating antihistamines

The medication is produced by UCB, a Belgian pharmaceutical company. The drug is marketed under the following brand names: Zyrtec® in the USA, Zirtek® in the United Kingdom, Zyrlex® in many other European countries, Reactine® in Canada (all by Pfizer ), and as Virlix® in Mexico and parts of Europe (by GlaxoSmithKline ). It can be found under a variety of other brand names in other countries .

Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine hydrochloride, a decongestant. These combinations are marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D®, Virlix-D®, etc.)

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Teva Pharmaceutical
From Drug Store News, 10/11/04 by James Frederick

Teva Pharmaceutical was granted tentative approval for its cetirizine HCl tablets in 5 mg and 10 mg dosings. Final approval is anticipated upon expiration of patent protection on Dec. 25, 2007.

Teva's cetirizine tablets are the generic equivalent to Pfizer s antihistamine product Zyrtec tablets, which posted annual sales of about $1.2 billion last year. Zyrtec already has been recommended for Rx-to-OTC switch approval by a pair of FDA advisory committees.

COPYRIGHT 2004 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2004 Gale Group

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