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Choriocarcinoma

Choriocarcinoma is a malignant and aggressive cancer of the placenta. It is characterized by early hematogenous spread to the lungs. more...

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Medicines

Etiology/Epidemiology

It is preceded by

  • hydatidiform mole (50% of cases)
  • abortion of ectopic pregnancy (20% of cases)
  • normal term pregnancy (20-30% of cases)

Symptoms/Signs/Labs

  • increased β-hCG levels
  • vaginal bleeding

Pathology

On light microscopy, there is malignant trophoblastic proliferation without hydropic villi.

Treatment

Choriocarcinoma is one of the tumors that is most sensitive to chemotherapy. The cure rate, even for metastatic choriocarcinoma, is around 90-95%. Virtually everyone without metastases can be cured. Chemotherapy regimen include Methotrexate or dactinomycin.

Hysterectomy (surgical removal of the uterus) can also be offered to patients > 40 years of age or those desiring sterilization. It may be required for those with severe infection and uncontrolled bleeding.

Read more at Wikipedia.org


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The diagnosis of hydatidiform mole, malignant hydatidiform mole and choriocarcinoma with special reference to the diagnostic value of pelvic arteriography, $125.00 Trophoblastic growths,: A clinical, hormonal and histopathologic study of hydatidiform mole and chorionepithelioma $54.50
Choriocarcinoma and related gestational trophoblastic tumors in women $50.00 Metastatic choriocarcinoma : An unusual cause of severe anaemia.(Images in Pathology) : An article from: Journal of Postgraduate Medicine $5.95
Gale Encyclopedia of Medicine : Choriocarcinoma $3.90 Choriocarcinoma: A study of its pathology, $28.00
Membranous glomerulonephritis in a patient with choriocarcinoma: case report. (Case Report). : An article from: Southern Medical Journal $5.95 Choriocarcinoma: The clinical biology of the trophoblast and its tumours
A case of deciduoma malignum

Massive hemoptysis: a case of metastatic choriocarcinoma
INTRODUCTION: Choriocarcinoma is a rare tumor in men, comprising less than 5% of germ cell tumors and frequently associated with an elevated serum beta-human ...
Use of urine pregnancy test for rapid diagnosis of primary pulmonary choriocarcinoma in a man - selected reports
Primary pulmonary choriocarcinoma is an extremely rare tumor in men, with 13 cases reported in the literature. Due to its rarity, primary choriocarcinoma ...
Choriocarcinoma in the pulmonary artery treated with emergency pulmonary embolectomy
A 42-year-old woman with choriocarcinoma required emergency pulmonary embolectomy under cardiopulmonary bypass. After diagnosis of choriocarcinoma was ...
Unusual case of choriocarcinoma occurring 12 months after delivery - Lesson of the Week
Choriocarcinoma is a malignant tumor which can occur years after a normal birth and should be considered as a possible diagnosis in women with acute hemorrhage.
Does primary pulmonary choriocarcinoma really exist? - Letter to the Editor
To the Editor: We read with interest the article by Tsai et al (March 2002) (1) but several points make us doubtful about the diagnosis of primary ...
Primary gastric choriocarcinoma: A case report and review of the literature
Choriocarcinoma is a rapidly invasive, widely metastatic human chorionic gonadotropin (HCG)-producing neoplasm, usually intrauterine and gestational.
Primary testicular choriocarcinoma with pulmonary metastases presenting as ARDS - adult respiratory distress syndrome
We report a case in which ARDS was the presenting manifestation of testicular choriocarcinoma with numerous metastases to the lungs. We also review ...
Ultrasonography and color Doppler imaging of metastatic pulmonary choriocarcinoma
Chest ultrasound and color Doppler flow imaging were used to assess the pulmonary nodule of a 24-year-old pregnant woman with dyspnea and hemoptysis.

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