Tadalafil structure
Find information on thousands of medical conditions and prescription drugs.

Cialis

Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis. It works by inhibiting an enzyme known as PDE5. Due to its 36-hour effect it is also known as the "Weekend Pill". In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003. more...

Home
Diseases
Medicines
A
B
C
Cabergoline
Caduet
Cafergot
Caffeine
Calan
Calciparine
Calcitonin
Calcitriol
Calcium folinate
Campath
Camptosar
Camptosar
Cancidas
Candesartan
Cannabinol
Capecitabine
Capoten
Captohexal
Captopril
Carbachol
Carbadox
Carbamazepine
Carbatrol
Carbenicillin
Carbidopa
Carbimazole
Carboplatin
Cardinorm
Cardiolite
Cardizem
Cardura
Carfentanil
Carisoprodol
Carnitine
Carvedilol
Casodex
Cataflam
Catapres
Cathine
Cathinone
Caverject
Ceclor
Cefacetrile
Cefaclor
Cefaclor
Cefadroxil
Cefazolin
Cefepime
Cefixime
Cefotan
Cefotaxime
Cefotetan
Cefpodoxime
Cefprozil
Ceftazidime
Ceftriaxone
Ceftriaxone
Cefuroxime
Cefuroxime
Cefzil
Celebrex
Celexa
Cellcept
Cephalexin
Cerebyx
Cerivastatin
Cerumenex
Cetirizine
Cetrimide
Chenodeoxycholic acid
Chloralose
Chlorambucil
Chloramphenicol
Chlordiazepoxide
Chlorhexidine
Chloropyramine
Chloroquine
Chloroxylenol
Chlorphenamine
Chlorpromazine
Chlorpropamide
Chlorprothixene
Chlortalidone
Chlortetracycline
Cholac
Cholybar
Choriogonadotropin alfa
Chorionic gonadotropin
Chymotrypsin
Cialis
Ciclopirox
Cicloral
Ciclosporin
Cidofovir
Ciglitazone
Cilastatin
Cilostazol
Cimehexal
Cimetidine
Cinchophen
Cinnarizine
Cipro
Ciprofloxacin
Cisapride
Cisplatin
Citalopram
Citicoline
Cladribine
Clamoxyquine
Clarinex
Clarithromycin
Claritin
Clavulanic acid
Clemastine
Clenbuterol
Climara
Clindamycin
Clioquinol
Clobazam
Clobetasol
Clofazimine
Clomhexal
Clomid
Clomifene
Clomipramine
Clonazepam
Clonidine
Clopidogrel
Clotrimazole
Cloxacillin
Clozapine
Clozaril
Cocarboxylase
Cogentin
Colistin
Colyte
Combivent
Commit
Compazine
Concerta
Copaxone
Cordarone
Coreg
Corgard
Corticotropin
Cortisone
Cotinine
Cotrim
Coumadin
Cozaar
Crestor
Crospovidone
Cuprimine
Cyanocobalamin
Cyclessa
Cyclizine
Cyclobenzaprine
Cyclopentolate
Cyclophosphamide
Cyclopropane
Cylert
Cyproterone
Cystagon
Cysteine
Cytarabine
Cytotec
Cytovene
Isotretinoin
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Chemical information

The empirical formula for tadalafil is C22H19N3O4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazinopyridoindole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. A 20mg dose of Tadalafil is comparable to a 100mg dose of sildenafil (Viagra). The MSDS for this compound can be found here:

Side effects

The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.

In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, e.g. diabetics. An investigation is currently ongoing.

Drug interactions

Organic nitrates

Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates within this timeframe may increase the risk of life-threatening hypotension. Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina, these patients should seek immediate medical attention if they experience anginal chest pain . In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.

Marketing

In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR.

Trivia

  • The word "specialist" is frequently caught by primitive spam email blockers because it contains the word "cialis."

Read more at Wikipedia.org


[List your site here Free!]


The big turnoff: stymied by politics and viagra, sex research goes limp
From Psychology Today, 1/1/05 by Justin Clark

IN THE SUMMER of 2003, a group of conservative members of Congress forced an audit of publicly funded sex studies, questioning the value of research derived from Asian prostitutes in San Francisco or everyday sexual risk-taking.

No legislation actually materialized from Congress--an amendment in the House of Representatives was defeated by two votes.

But a few months later, the Boston University Sexuality and Research Treatment Program quietly shut its doors. The National Institute of Mental Health had withdrawn funding, effectively closing down the 20-year-old program and its research into human sexual arousal.

Across the country, sex researchers are more worried about death than sex--that is, the slow demise of their own field. In the past year, conservative groups have pressured federal agencies to look long and hard at their spending plans. In a time of war and budget deficits, "these particular [National Institutes of Health] grants are simply not a wise use of taxpayer money," says Republican congressman Jeff Flake of Arizona.

Even the mere threat of funding cuts has had subversive effects, researchers say. It has, for example, forced many sex researchers to turn to drug companies for sponsorship. And that, according to Lenore Tiefer, professor of psychiatry at New York University, is ruining the sex lives of many Americans.

Sex researchers' dependence on pharmaceutical money, she says, has translated into a popular view that any sexual problem can be treated with a pill. As a consequence, sex research is drowning under "a tidal wave of reductionism, wherein sex is pelvic vascular function," says Tiefer. Drugs like Viagra, Cialis and Levitra are now the mass panacea for a flagging sex drive.

The critical questions of how emotions influence sexual feelings are no longer asked, researchers complain. They also say that whether the motive is political or financial, sex research has been diverted far from its original mission--deepening our understanding of this critical aspect of human behavior in a way that benefits all of society.

Sweeping the psychological side of sex under the rug in favor of the mechanical will ultimately hinder our understanding of the human condition, says Geoffrey Miller, an evolutionary psychologist and author of The Mating Mind. "If scientific funding agencies took on the goal of happiness as their responsibility, they would put sex research at the heart of the behavioral sciences."

Miller cites his own studies on kissing--why long-term couples often kiss less as the years go by and why people find kissing enjoyable in the first place--as examples of "a dark continent of research" that some would say is of questionable value. Studying the benefits of kissing could help couples rejuvenate a marriage and reduce divorce rates, says Miller, "but it's less threatening and more profitable to study orgasms."

What do conservative congressmen and others find so threatening? Childhood and adolescent sexuality, for starters. Few people want to acknowledge that children have sexual feelings, says Ohio State University psychologist Terri Fisher, yet adult sexual problems may have their origins in childhood. The issue is so taboo, she notes, that "we don't know how child sexuality bears on adult sexuality because no one has ever done a longitudinal study."

Another threat may be the suggestion that some sexual behavior considered undesirable--like infidelity--has deep roots in human nature. Miller's studies suggest that women's mate preferences vary during the menstrual cycle: At the peak of fertility women prefer handsome and creative men, but when fertility is low, they value men of social status and earning power. In other words, he says, women's divergent interests may lead them to cheat on a partner.

Pedophilia and sexual trauma are two topics unlikely to draw research funds from drug conglomerates or organizations under scrutiny in the current political climate. And yet these societal menaces could be better understood through the study of sexual arousal, "which we're on the verge of understanding," observes Janet Hyde, head of the psychology department at the University of Wisconsin.

Not all the objections to sexual research come from the political right. Feminists worry that any research that shows most sexual behavior is hardwired could be used to revive notions of females as a weaker or more irrational sex.

Ultimately, understanding the emotional and relational roots of sexuality is in society's best interests. It will provide a more direct route to satisfying relationships than drugs can, says University of New Brunswick researcher Sandra Byers. "Sexual satisfaction isn't just the absence of a problem, any more than happiness is the absence of depression."

COPYRIGHT 2005 Sussex Publishers, Inc.
COPYRIGHT 2005 Gale Group

Return to Cialis
Home Contact Resources Exchange Links ebay