Ciprofloxacin chemical structure
Find information on thousands of medical conditions and prescription drugs.

Cipro

Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand names Cipro® and Ciproxin® (and other brand names in other markets, e.g. veterinary drugs), belonging to a group called fluoroquinolones. Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. more...

Home
Diseases
Medicines
A
B
C
Cabergoline
Caduet
Cafergot
Caffeine
Calan
Calciparine
Calcitonin
Calcitriol
Calcium folinate
Campath
Camptosar
Camptosar
Cancidas
Candesartan
Cannabinol
Capecitabine
Capoten
Captohexal
Captopril
Carbachol
Carbadox
Carbamazepine
Carbatrol
Carbenicillin
Carbidopa
Carbimazole
Carboplatin
Cardinorm
Cardiolite
Cardizem
Cardura
Carfentanil
Carisoprodol
Carnitine
Carvedilol
Casodex
Cataflam
Catapres
Cathine
Cathinone
Caverject
Ceclor
Cefacetrile
Cefaclor
Cefaclor
Cefadroxil
Cefazolin
Cefepime
Cefixime
Cefotan
Cefotaxime
Cefotetan
Cefpodoxime
Cefprozil
Ceftazidime
Ceftriaxone
Ceftriaxone
Cefuroxime
Cefuroxime
Cefzil
Celebrex
Celexa
Cellcept
Cephalexin
Cerebyx
Cerivastatin
Cerumenex
Cetirizine
Cetrimide
Chenodeoxycholic acid
Chloralose
Chlorambucil
Chloramphenicol
Chlordiazepoxide
Chlorhexidine
Chloropyramine
Chloroquine
Chloroxylenol
Chlorphenamine
Chlorpromazine
Chlorpropamide
Chlorprothixene
Chlortalidone
Chlortetracycline
Cholac
Cholybar
Choriogonadotropin alfa
Chorionic gonadotropin
Chymotrypsin
Cialis
Ciclopirox
Cicloral
Ciclosporin
Cidofovir
Ciglitazone
Cilastatin
Cilostazol
Cimehexal
Cimetidine
Cinchophen
Cinnarizine
Cipro
Ciprofloxacin
Cisapride
Cisplatin
Citalopram
Citicoline
Cladribine
Clamoxyquine
Clarinex
Clarithromycin
Claritin
Clavulanic acid
Clemastine
Clenbuterol
Climara
Clindamycin
Clioquinol
Clobazam
Clobetasol
Clofazimine
Clomhexal
Clomid
Clomifene
Clomipramine
Clonazepam
Clonidine
Clopidogrel
Clotrimazole
Cloxacillin
Clozapine
Clozaril
Cocarboxylase
Cogentin
Colistin
Colyte
Combivent
Commit
Compazine
Concerta
Copaxone
Cordarone
Coreg
Corgard
Corticotropin
Cortisone
Cotinine
Cotrim
Coumadin
Cozaar
Crestor
Crospovidone
Cuprimine
Cyanocobalamin
Cyclessa
Cyclizine
Cyclobenzaprine
Cyclopentolate
Cyclophosphamide
Cyclopropane
Cylert
Cyproterone
Cystagon
Cysteine
Cytarabine
Cytotec
Cytovene
Isotretinoin
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Activity

Ciprofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

  • Enterobacteriaceae
  • Vibrio
  • Haemophilus influenzae
  • Neisseria gonorrhoeae
  • Neisseria menigitidis
  • Moraxella catarrhalis
  • Brucella
  • Campylobacter
  • Mycobacterium intracellulare
  • Legionella sp.
  • Pseudomonas aeruginosa
  • Bacillus anthracis - that causes anthrax

Weak activity against:

  • Streptococcus pneumoniae
  • Chlamydia trachomatis
  • Chlamydia pneumoniae

No activity against:

  • Bacteroides
  • Burkholderia cepacia
  • Enterococcus faecium
  • Ureaplasma urealyticum
  • and others

The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a "last-resort" drug for use on difficult and drug-resistant infections. As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals, which leads to greater and more rapid weight gain, for reasons which are not clear.

Label information

The drug is available for oral and parenteral use. It is used in lower respiratory infections (pneumonias), urinary tract infections, STDs, septicemias, Legionellosis and atypical Mycobacterioses. Dosage in respiratory infections is 500-1500 mg a day in 2 doses.

It is contraindicated in children, pregnancy, and in patients with epilepsy. Dose adjustment or avoidance may be necessary with liver or renal failure.

Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values. It can also cause constipation and sensitivity to caffeine.

Interactions

Quercetin, a flavonoid occasionally used as a dietary supplement may interact with fluroquinolones, as quercetin competitively binds to bacterial DNA gyrase. Some foods such as garlic and apples contain high levels of quercetin. Whether this inhibits or enhances the effect of Fluoroquinolones is not immediately clear.

Read more at Wikipedia.org


[List your site here Free!]


Online Cipro: Caveat Emptor
From PC Magazine, 12/4/01 by Christina Wood

Like public health concerns over anthrax, the number of online shops hawking the antibiotic Cipro has blossomed. Drug-dispensing Web sites have existed for a long time, but their impact used to be less dramatic, as they dealt in the relatively innocuous realm of Viagra, diet pills, birth control pills, steroids, and hair-loss medications. Their target consumers were merely those who were unwilling or unable to get legitimate prescriptions.

Thus the problem of drug sales over the Net remained in the shadows. Although the FDA and various states closed down many domestic online pharmaceutical operations that they deemed illegal, the average consumer didn't really notice. But in the month following the first anthrax death, so many Web sites started popping up to sell Cipro that the FDA and the FTC began issuing warnings to consumers, urging caution and telling potential customers to avoid rogue sites.

A Google search for Cipro returns dozens of hits for sites selling anthrax "protection kits" that require nothing more than a credit card number. Such offers are extremely tempting for people caught in the grip of fear. And by selling Cipro, the rogue pharmaceutical sites have seriously upped the ante for risk factors, because the drug is an antibiotic that should be consumed only when appropriate and safely monitored. (Cipro can have nasty side effects that might be acceptable if you've been exposed to anthrax, but not just to quell your fear.)

Online and Aboveboard?

The majority of sites that sell Cipro over the Net with "no hassle, no prescription" are overseas outfits that can get away with this because our domestic agencies have no jurisdiction over them. But the FDA is doing what it can to stop scamsters from capitalizing on Americans' fear and is "taking several actions to halt potentially illicit drug sales."

In early November, the FDA issued cyberletters to foreign Web sites selling unapproved Cipro. The letters warned the sites that they could be violating U.S. law if the Cipro they're selling to Americans doesn't conform to FDA standards. And the U.S. Customs Service is taking measures to seize questionable prescription drug shipments when they enter the country.

Of course, there are online pharmacies that are completely aboveboard: drugstore.com, Walgreens online, and many others are legal and convenient services that handle prescription refills. (Look for the VIPPS seal from the National Association of Boards of Pharmacy, www.nabp.net.) But those sites won't sell you medication unless you have a prescription. Though they may not be as convenient as feeding a credit card number to some Web site based in Fiji, they are at least reputable.

The thing I find most frightening about the sale of drugs online is the unknown. Like scam operators all over the Net, the people behind the sites might not be who they say they are. They may not send you anything for your money, or even worse, they might not send you the pills you were expecting. Since the FDA can't oversee the manufacture of drugs it hasn't approved, it can't verify the ingredients of those pills. You could end up with a useless sugar pill or one that is tainted with dangerous substances.

Unknown Sources

To be honest, I am astounded by the absurdity—and the irony—of the scenario. I can certainly understand calling out a Hazmat team or going to a doctor over the remote possibility of anthrax exposure. But if you are afraid of exposing yourself to a suspicious substance from an unknown source like unmarked mail, does it really make sense to order a suspicious substance from a different unknown source? When these rogue sites were hawking Viagra and diet pills, the danger of the drugs and the reach of the sellers were smaller.

The implications of stepping into the unknown world of illicit online drug purchases are profound. Widespread use of Cipro when it isn't needed could create a public health hazard. And the danger that some of these drugs may be counterfeit—a real problem in other countries—means there is no telling where this might lead. At the very least, succumbing to the temptation allows yet another hazard in the door.

Discuss this article in the forum

Copyright © 2004 Ziff Davis Media Inc. All Rights Reserved. Originally appearing in PC Magazine.

Return to Cipro
Home Contact Resources Exchange Links ebay