Ciprofloxacin chemical structure
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Cipro

Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand names Cipro® and Ciproxin® (and other brand names in other markets, e.g. veterinary drugs), belonging to a group called fluoroquinolones. Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. more...

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Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Activity

Ciprofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

  • Enterobacteriaceae
  • Vibrio
  • Haemophilus influenzae
  • Neisseria gonorrhoeae
  • Neisseria menigitidis
  • Moraxella catarrhalis
  • Brucella
  • Campylobacter
  • Mycobacterium intracellulare
  • Legionella sp.
  • Pseudomonas aeruginosa
  • Bacillus anthracis - that causes anthrax

Weak activity against:

  • Streptococcus pneumoniae
  • Chlamydia trachomatis
  • Chlamydia pneumoniae

No activity against:

  • Bacteroides
  • Burkholderia cepacia
  • Enterococcus faecium
  • Ureaplasma urealyticum
  • and others

The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a "last-resort" drug for use on difficult and drug-resistant infections. As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals, which leads to greater and more rapid weight gain, for reasons which are not clear.

Label information

The drug is available for oral and parenteral use. It is used in lower respiratory infections (pneumonias), urinary tract infections, STDs, septicemias, Legionellosis and atypical Mycobacterioses. Dosage in respiratory infections is 500-1500 mg a day in 2 doses.

It is contraindicated in children, pregnancy, and in patients with epilepsy. Dose adjustment or avoidance may be necessary with liver or renal failure.

Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values. It can also cause constipation and sensitivity to caffeine.

Interactions

Quercetin, a flavonoid occasionally used as a dietary supplement may interact with fluroquinolones, as quercetin competitively binds to bacterial DNA gyrase. Some foods such as garlic and apples contain high levels of quercetin. Whether this inhibits or enhances the effect of Fluoroquinolones is not immediately clear.

Read more at Wikipedia.org


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It's time to separate anthrax fact from fiction - other antibiotics just as good as Cipro against anthrax - Brief Article
From Drug Store News, 11/5/01 by James Frederick

A handful of sickos--who may or may not be tied to Al Qaeda, Osama bin Laden or Saddam Hussein--has managed to ratchet up the country's already high level of wartime anxiety by mailing anthrax-dusted letters to key government and media centers. Besides killing more innocent people, which seems to be their specialty, these terrorists and their sinister little biobombs are breeding a climate of paranoia and misinformation about the dangers of anthrax and the need for Bayer's antibiotic drug Cipro.

As senior pharmacy editor Diane West so ably points out in her story in this issue, there are at least a couple of dangerous myths surrounding the current stampede by many Americans to get Cipro. One is the fact that the drug isn't unique in its ability to treat inhaled or cutaneous anthrax infection -- if taken early. Other antibiotics apparently are just as effective.

Indeed, said one advisor to Health and Human Services secretary Tommy Thompson who was quoted in The Wall Street Journal, "Those implementing the [anthrax treatment and Cipro acquisition] program have forgotten the fact that penicillin and doxycycline are equally as good" at treating the condition.

"We must reinforce this," said Donald Henderson, who also referred in an Oct. 24 Journal story to the "hysteria" by consumers, companies and government agencies to obtain Cipro.

That hasn't stopped the governments of the United States and Canada from stockpiling Cipro, or from cutting deals with Bayer to acquire the drug at a far cheaper, but still-expensive price of around a dollar a pill. It hasn't slowed demand for supplies of Cipro from online pharmacy retailers. And it hasn't ended the pressure many fearful Americans are exerting on their physicians to obtain a prescription for the drug.

But there's a more dangerous myth at work, as well: that a majority of Americans should be taking "preventive" doses of antibiotics or, even worse, plying their children with them. What better way to breed drug-resistant supergerms than this? And what a sad legacy for America, if the current threat of bioterrorism leaves many patients even more at risk for new generations of infectious diseases that no longer respond to treatment with antibiotics?

In short, the United States is awash in the current anthrax scare. But posting signs in the windows that tell already anxious customers 'We have Cipro"--as some pharmacies are reportedly doing--doesn't help. On the contrary, it heightens tensions and feeds the hysteria surrounding the current anthrax scare.

Pharmacists, of all health care professionals, should be on the front lines of a nationwide effort to explode myths about anthrax and antibiotics. Who is in a better position to educate patients and calm irrational fears? And who better to help prevent a nationwide rush to consume Cipro and other antibiotics as an anthrax "preventive" by dispensing sound information, as well as medicines?

The National Association of Chain Drug Stores has issued a set of guidelines for pharmacists to help answer consumers' questions about the use of Cipro and other antibiotics. Those guidelines wisely point up the dangers of over prescribing, as well as the potential side effects some patients could experience with Cipro and other meds.

Drug retailers would do well to post those guidelines in their pharmacies. But they can do more. Pharmacy leaders talk constantly about the important role pharmacists can play as partners in a comprehensive community health care system. This is a perfect time to prove it.

To me, the anthrax scare cries out for the forging of closer links between physicians and pharmacists, as partners in a nationwide effort to inform patients and shed light on a subject that breeds fear and dangerous misinformation. And what better time for all health care professionals to work together to craft a common message for patients about the proper use of medications and the dangers of overprescribing?

COPYRIGHT 2001 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2001 Gale Group

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