Ciprofloxacin chemical structure
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Ciprofloxacin

Ciprofloxacin is the generic international name for the synthetic antibiotic manufactured and sold by Bayer Pharmaceutical under the brand names Cipro® and Ciproxin® (and other brand names in other markets, e.g. veterinary drugs), belonging to a group called fluoroquinolones. Ciprofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. more...

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Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Activity

Ciprofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

  • Enterobacteriaceae
  • Vibrio
  • Haemophilus influenzae
  • Neisseria gonorrhoeae
  • Neisseria menigitidis
  • Moraxella catarrhalis
  • Brucella
  • Campylobacter
  • Mycobacterium intracellulare
  • Legionella sp.
  • Pseudomonas aeruginosa
  • Bacillus anthracis - that causes anthrax

Weak activity against:

  • Streptococcus pneumoniae
  • Chlamydia trachomatis
  • Chlamydia pneumoniae

No activity against:

  • Bacteroides
  • Burkholderia cepacia
  • Enterococcus faecium
  • Ureaplasma urealyticum
  • and others

The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics. Because of its general safety, potency and broad spectrum activity, ciprofloxacin was initially reserved as a "last-resort" drug for use on difficult and drug-resistant infections. As with any antibiotic, however, increasing time and usage has led to an increase in ciprofloxacin-resistant infections, mainly in the hospital setting. Also implicated in the rise of resistant bacteria is the use of lower-cost, less potent fluoroquinolones, and the widespread addition of ciprofloxacin and other antibiotics to the feed of farm animals, which leads to greater and more rapid weight gain, for reasons which are not clear.

Label information

The drug is available for oral and parenteral use. It is used in lower respiratory infections (pneumonias), urinary tract infections, STDs, septicemias, Legionellosis and atypical Mycobacterioses. Dosage in respiratory infections is 500-1500 mg a day in 2 doses.

It is contraindicated in children, pregnancy, and in patients with epilepsy. Dose adjustment or avoidance may be necessary with liver or renal failure.

Ciprofloxacin can cause photosensitivity reactions and can elevate plasma theophylline levels to toxic values. It can also cause constipation and sensitivity to caffeine.

Interactions

Quercetin, a flavonoid occasionally used as a dietary supplement may interact with fluroquinolones, as quercetin competitively binds to bacterial DNA gyrase. Some foods such as garlic and apples contain high levels of quercetin. Whether this inhibits or enhances the effect of Fluoroquinolones is not immediately clear.

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Fluoroquinolone resistance in Campylobacter jejuni isolates in travelers returning to Finland: association of ciprofloxacin resistance to travel destination
From Emerging Infectious Diseases, 2/1/03 by Antti Hakanen

Ciprofloxacin resistance was analyzed in 354 Campylobacter jejuni isolates collected during two study periods (1995-1997 and 1998-2000) from travelers returning to Finland. The increase in resistance between the two periods was significant among all isolates (40% vs. 60%; p<0.01), as well as among those from Asia alone (45% vs. 72%; p<0.01).

**********

Campylobacter jejuni isolates are naturally susceptible to fluoroquinolones (1,2). During the 1990s, however, fluoroquinolone resistance in Campylobacter rapidly increased in several countries (3). In Thailand and Spain, for example, up to 80% of Campylobacter isolates are fluoroquinolone-resistant (4,5). However, major differences in Campylobacter fluoroquinolone resistance levels are known to occur, and in many parts of the world fluoroquinolone resistance levels remain low (3). This study was performed to evaluate the level of fluoroquinolone resistance in C. jejuni isolates from travelers returning to Finland and to specify the countries where resistant isolates are acquired.

The Study

Our study included 354 clinical human fecal C. jejuni isolates collected from travelers returning to Finland from 1995 to 2000. The isolates were collected in two different phases from the laboratory of a large private hospital in Helsinki, Finland. Participants were treated as outpatients, and no data on antimicrobial usage before fecal sampling were available; all participants had a history of traveling abroad within the preceding 2 weeks. From January 1995 to November 1997, we consecutively collected 205 isolates, and from October 1998 to January 2000, 149 isolates. The isolates were cultured and identified by standard microbiologic methods (6). MICs of ciprofloxacin and nalidixic acid for the isolates were determined by the agar plate dilution method, as described (7). C. jejuni RH 3583 (a local control strain, originally isolated in Edinburgh, U.K., C. jejuni 143483) was used as a control in susceptibility testing and also as a growth control strain. The MIC breakpoint used for the resistance to ciprofloxacin was that recommended by the National Committee for Clinical Laboratory Standards (NCCLS) for non-Enterobacteriaceae (8). To nalidixic acid, the breakpoints were those recommended by NCCLS for Enterobacteriaceae (8).

Data concerning the numbers of travels from Finland to countries of interest (i.e., countries with the largest numbers of all C. jejuni isolates or of ciprofloxacin-resistant isolates) during the study months were received from Statistics Finland (available from: URL: www.stat.fi/). The susceptibility data were analyzed by using the WHONET5 computer program (available from: URL: www.who.int/emcWHONET/WHONET.html).

Statistical analysis was made by using the chi-square test and the Fisher exact test. Differences between C. jejuni infection rates in travelers returning from various travel destinations were statistically tested with Poisson regression analysis. Differences were quantified with infection rates and 95% confidence intervals; p values of <0.05 were considered significant. Statistical data were analyzed by using the SAS system for Windows, release 8.2/2001 (SAS Institute, Inc., Cary, NC).

Of the 354 C. jejuni isolates studied, the country where campylobacteriosis was acquired could be identified for 319 isolates, collected from travelers to 40 different countries. The origin of 22 isolates was traced at least to a continental level; the patients involved had several travel destinations. The origin of 13 isolates remained unknown. The most common countries of origin were Spain with 77 (22%) isolates, Thailand with 50 (14%) isolates, and India with 23 (6%) isolates. During the first study period (1995-1997), 205 isolates were collected from travelers. Of the 34 countries of origin that were identified, the most common were Spain with 40 (20%) isolates, India with 19 (9%) isolates, and Thailand and Turkey, both with 17 (8%) isolates. During the second study period (1998-2000), 149 isolates were collected from travelers; of the 25 countries of origin identified, the most common were Spain with 37 (25%) isolates, Thailand with 33 (22%) isolates, and Portugal and Tunisia, both with 6 (4%) isolates.

Of all 354 C. jejuni isolates, 172 (49%) were resistant to ciprofloxacin. Of the 205 isolates collected in 1995-1997, 82 (40%) were resistant to ciprofloxacin compared with 90 (60%) of the 149 isolates collected in 1998-2000 (p<0.01). When analyzed by continent, the increase in fluoroquinolone resistance between these two periods was significant among the isolates from Asia alone (45% vs. 72%, p<0.01; Table 1). An increasing tendency for fluoroquinolone resistance was also observed in the isolates from the three additional continents. The numbers and proportions of ciprofloxacin-resistant isolates collected from travelers returning from Spain and Thailand, the two most common countries of origin, were analyzed separately. During the first and second collection periods, the respective numbers and proportions of ciprofloxacin-resistant isolates were 29 (73%) and 26 (70%) in the isolates from Spain, and 13 (77%) and 26 (79%) in the isolates from Thailand. To assess whether the larger proportion of isolates from Thailand during the second period (8% vs. 22%) explained the significant increase in fluoroquinolone resistance in the whole study group, we analyzed the data excluding all isolates from Thailand. The increase in ciprofloxacin resistance, from 37% to 55%, was still significant (p<0.01). A corresponding analysis that excluded all isolates from both Spain and Thailand resulted in an increase in ciprofloxacin resistance from 27% to 48% (p<0.01).

The number of ciprofloxacin-resistant C. jejuni isolates collected was compared with the estimated numbers of all trips from Finland during the study period to the five most frequent countries of origin for the ciprofloxacin-resistant isolates. These speculative infection rates were used to calculate rate ratios between these countries. Because the speculative infection rate by fluoroquinolone-resistant C. jejuni isolates was highest in travelers returning from Thailand, that country was used as the reference in the rate ratio comparisons. The rate ratios by fluoroquinolone-resistant isolates in travelers returning from Spain and Portugal were 0.11 in both groups; the differences were statistically significant compared with the ratios for the reference country (p<0.01 for both; Table 2). The corresponding rate ratios in travelers returning from India and China were 0.90 and 0.72, respectively; these differences were not significant.

Conclusions

We have shown that ciprofloxacin resistance significantly increased (from 40% to 60%; p<0.01) during the study period among all C. jejuni isolates from travelers. The increase was also significant in isolates from Asia alone, suggesting a continual presence of selection pressure for the emergence of fluoroquinolone resistance on that continent. Moreover, an increasing tendency in ciprofloxacin resistance was observed in isolates from three additional continents, but either the increase (from 44% to 51% in Europe) or the number of isolates (7 isolates from America and 32 isolates from Africa) was small, and the changes were not statistically significant. Throughout the study, the rates of ciprofloxacin resistance remained on a high level in Spain and Thailand, the two most frequent countries of origin for all foreign isolates, as well as for resistant isolates. The fact that the increase in ciprofloxacin resistance remained significant even after all isolates from Spain and Thailand were excluded from the analysis illustrates that the emergence and spread of fluoroquinolone-resistant C. jejuni are not restricted to a few highly Campylobacterendemic countries. Rather, these findings show that C. jejuni fluoroquinolone resistance, which manifested at the beginning of the 1990s, continues to grow rapidly in many parts of the world.

Several studies have focused on the quinolone resistance of Campylobacter spp. In Spain, a rapid increase in quinolone resistance was observed after 1988, with up to 50% of C. jejuni isolates resistant by 1991 (9,10). In recent years, fluoroquinolone resistance rates among Spanish C. jejuni isolates have been reported to reach 80% (5); these findings are in accordance with the 70% to 73% resistance rates we observed in isolates from Spain. Similarly, the 77% to 79% rates of ciprofloxacin resistance among our isolates from Thailand concur with the surveillance data, indicating that fluoroquinolone resistance rates already exceed 80% in Thailand (4).

Our study provides data on C. jejuni fluoroquinolone resistance in 40 countries and on four continents, rendering possible the evaluation of the relative risk for a Finnish traveler to acquire an infection by ciprofloxacin-resistant C. jejuni in different travel destinations. When assessing the actual infection rate by ciprofloxacin-resistant C. jejuni in any destination, the number of ciprofloxacin-resistant C. jejuni isolates imported from that destination during the study months should be divided by the number of simultaneous trips from Finland. In our study, the total number of resistant C. jejuni isolates imported to Finland was not known, since we examined isolates from one hospital only. Thus, when the numbers of ciprofloxacin-resistant C. jejuni isolates identified were divided by the simultaneous numbers of trips from the whole country, the figures (referred to as speculative infection rates in Table 2) did not provide any real data on infection rates by resistant isolates. Nevertheless, these figures could be used to calculate rate ratios between different travel destinations. Despite the high proportions of ciprofloxacin-resistant isolates in Spain (71%) and Portugal (64%), the risk of acquiring fluoroquinolone-resistant campylobacteriosis appeared to be 10 times smaller in those countries than in Thailand. These results are in line with our previous results, which showed that a tourist's risk of acquiring quinolone-resistant salmonellosis was significantly higher in Thailand and Malaysia than in other travel destinations (11).

In conclusion, we demonstrated a significant increase in ciprofloxacin resistance among all C. jejuni travelers' isolates, as well as among the isolates from Asia alone. The rate of ciprofloxacin resistance remained on a high level throughout the study in Spain and Thailand, the two most frequent countries of origin of the ciprofloxacin-resistant isolates. These data support the concept of continuous selection pressure for the emergence and spread of fluoroquinolone resistance not only in Asia but also in many other parts of the world. Efforts should be made to elucidate and alleviate the factors behind this selection pressure.

Acknowledgments

We are indebted to Jari Ahvenainen for statistical assistance; Ritva Marin for providing data on passenger statistics; and Liisa Immonen, Minna Lamppu, Tarja Laustola, Marja-Liisa Lindman, Satu Linko, Tiina Muuronen, Erkki Nieminen, Saija Nylander, and all the staff members at the laboratories of the study for expert technical assistance.

This study was supported by grants from the Maud Kuistila Memorial Foundation, the Finnish Medical Foundation Duodecim, and the special government grant (EVO grant) from Turku University Central Hospital (all to A.H.).

References

(1.) Fliegelman RM, Petrak RM, Goodman LJ, Segreti J, Trenholme GM, Kaplan RL. Comparative in vitro activities of twelve antimicrobial agents against Campylobacter species. Antimicrob Agents Chemother 1985;27:429-30.

(2.) Lariviere LA, Gaudreau CL, Turgeon FF. Susceptibility of clinical isolates of Campylobacter jejuni to twenty-five antimicrobial agents. J Antimicrob Chemother 1986;18:681-5.

(3.) Engberg J, Aarestrup FM, Taylor DE, Gerner-Smidt P, Nachamkin I. Quinolone and macrolide resistance in Campylobacter jejuni and C. coil: resistance mechanisms and trends in human isolates. Emerg Infect Dis 2001;7:24-34.

(4.) Hoge CW, Gambel JM, Srijan A, Pitarangsi C, Echeverria P. Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis 1998;26:341-5.

(5.) Ruiz J, Goni P, Marco F, Gallardo F, Mirelis B, Jimenez De Anta T, et al. Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates. Microbiol Immunol 1998;42:223-6.

(6.) Penner JL. Campylobacter, Helicobacter, and related spiral bacteria. In: Manual of clinical microbiology. 5th ed. Balows A, Hausler WJJ, Herrmann KL, Isenberg HD, Shadomy HJ, editors. Washington: American Society for Microbiology; 1991.

(7.) Hakanen A, Huovinen P, Kotilainen P, Siitonen A, Jousimies-Somer H. Quality control strains used in susceptibility testing of Campylobacter spp. J Clin Microbiol 2002;40:2705-6.

(8.) National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing: eleventh informational supplement. Vol. 21, No 1. Wayne (PA): The Committee; 2001. (NCCLS document no. M- 100-S11.)

(9.) Reina J, Ros MJ, Serra A. Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from feces of pediatric patients. Antimicrob Agents Chemother 1994;38:2917-20.

(10.) Sanchez R, Fernandez-Baca V, Diaz MD, Munoz P, Rodriguez-Creixems M, Bouza E. Evolution of susceptibilities of Campylobacter spp. to quinolones and macrolides. Antimicrob Agents Chemother 1994;38:187982.

(11.) Hakanen A, Kotilainen P, Huovinen P, Helenius H, Siitonen A. Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia. Emerg Infect Dis 2001;7:984-91.

Address for correspondence: Antti Hakanen, Antimicrobial Research Laboratory, National Public Health Institute, P.O. Box 57, 20521 Turku, Finland; fax. 358-2-2519254; e-mail: antti.hakanen@utu.fi

Antti Hakanen, * ([dagger]) Hannele Jousimies-Somer, ([double dagger]) ([section]) (1) Anja Siitonen, ([double dagger]) Pentti Huovinen, * and Pirkko Kotilainen ([dagger])

* National Public Health Institute, Turku, Finland; ([dagger]) Turku University Central Hospital, Turku, Finland; ([double dagger]) National Public Health Institute, Helsinki, Finland; and ([section]) Mehilainen Hospital, Helsinki, Finland

(1) Dr. Jousimies-Somer is deceased.

Dr. Hakanen is a research physician in the Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland. His research interest is focused on antimicrobial resistance of enteric pathogens.

COPYRIGHT 2003 U.S. National Center for Infectious Diseases
COPYRIGHT 2003 Gale Group

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