Chemical structure of desloratadine.3D Model of desloratadine.
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Clarinex

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn®, Claramax®, Clarinex® and Aerius®. It is an active metabolite of loratadine, which is also on the market. more...

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Available forms

Desloratadine is available as tablets and oral suspension.

Mechanism of action

Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. It is 10-20 times more potent as an antihistamine than loratadine.

Pharmacokinetics

Desloratadine is rapidly absorbed from the gastro-intestinal tract. Desloratadine is moderately bound to plasma proteins (85%). The half-life of desloratadine is on average 28 hours. About 40% is excreted as conjugated metabolites into the urine and similar amount into the feces. Traces of unmetabolised desloratadine can be found in the urine.

Side effects

Most common side-effects are fatigue, drowsiness, dry mouth, headache, and gastrointestinal disturbances.

Desloratadine vs. loratadine

A November 2003 article published in the journal American Family Physician about the safety, tolerability, effectiveness, price, and simplicity of desloratadine concluded the following:

Desloratadine is similar in effectiveness to fexofenadine and would be expected to produce results similar to loratadine and other nonsedating antihistamines. There is no clinical advantage to switching a patient from loratadine to desloratadine. However, it may be an option for patients whose medical insurance no longer covers loratadine if the co-pay is less than the cost of the over-the-counter product.

Read more at Wikipedia.org


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Wellpoint Health Networks - Supplier News - new guidelines on prescriptions Zyrtec, Allegra, and Clarinex - Brief Article
From Drug Store News, 10/7/02

Wellpoint Health Networks has implemented new guidelines on prescriptions of Pfizer s Zytrec, Aventis' Allegra and Schering-Plough's Clarinex. Wellpoint has placed the drugs in the highest co-pay tier and requires special physician approval to obtain the prescriptions. Health insurers Humana, Sierra Health Networks and UnitedHealth Group will follow Wellpoint's lead in incentivizing patients to take OTC Claritin by implementing similiar procedures, according to a news report.

In related news, Schering-Plough may not be the only loratadine OTC player come January. The U.S. District Court of New Jersey recently ruled that the exclusivity patent protecting Claritin did not extend through 2004 as Schering-Plough argued, but instead expires Dec. 19. The consumer health care divisions of both Wyeth and McNeil have each filed loratadine applications to the FDA. Schering-Plough appealed the decision.

COPYRIGHT 2002 Reproduced with permission of the copyright holder. Further reproduction or distribution is prohibited without permission.
COPYRIGHT 2002 Gale Group

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