Find information on thousands of medical conditions and prescription drugs.

Cloxacillin

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. It is sold under a number of trade names, including Cloxapen® and Orbenin®.

Cloxacillin is for use against staphylococci that produce beta-lactamase.

Molecular formula: C19H17ClN3O5S*Na*H2O

Molecular weight: 475.9

CAS registry no.: 7081-44-9

Home
Diseases
Medicines
A
B
C
Cabergoline
Caduet
Cafergot
Caffeine
Calan
Calciparine
Calcitonin
Calcitriol
Calcium folinate
Campath
Camptosar
Camptosar
Cancidas
Candesartan
Cannabinol
Capecitabine
Capoten
Captohexal
Captopril
Carbachol
Carbadox
Carbamazepine
Carbatrol
Carbenicillin
Carbidopa
Carbimazole
Carboplatin
Cardinorm
Cardiolite
Cardizem
Cardura
Carfentanil
Carisoprodol
Carnitine
Carvedilol
Casodex
Cataflam
Catapres
Cathine
Cathinone
Caverject
Ceclor
Cefacetrile
Cefaclor
Cefaclor
Cefadroxil
Cefazolin
Cefepime
Cefixime
Cefotan
Cefotaxime
Cefotetan
Cefpodoxime
Cefprozil
Ceftazidime
Ceftriaxone
Ceftriaxone
Cefuroxime
Cefuroxime
Cefzil
Celebrex
Celexa
Cellcept
Cephalexin
Cerebyx
Cerivastatin
Cerumenex
Cetirizine
Cetrimide
Chenodeoxycholic acid
Chloralose
Chlorambucil
Chloramphenicol
Chlordiazepoxide
Chlorhexidine
Chloropyramine
Chloroquine
Chloroxylenol
Chlorphenamine
Chlorpromazine
Chlorpropamide
Chlorprothixene
Chlortalidone
Chlortetracycline
Cholac
Cholybar
Choriogonadotropin alfa
Chorionic gonadotropin
Chymotrypsin
Cialis
Ciclopirox
Cicloral
Ciclosporin
Cidofovir
Ciglitazone
Cilastatin
Cilostazol
Cimehexal
Cimetidine
Cinchophen
Cinnarizine
Cipro
Ciprofloxacin
Cisapride
Cisplatin
Citalopram
Citicoline
Cladribine
Clamoxyquine
Clarinex
Clarithromycin
Claritin
Clavulanic acid
Clemastine
Clenbuterol
Climara
Clindamycin
Clioquinol
Clobazam
Clobetasol
Clofazimine
Clomhexal
Clomid
Clomifene
Clomipramine
Clonazepam
Clonidine
Clopidogrel
Clotrimazole
Cloxacillin
Clozapine
Clozaril
Cocarboxylase
Cogentin
Colistin
Colyte
Combivent
Commit
Compazine
Concerta
Copaxone
Cordarone
Coreg
Corgard
Corticotropin
Cortisone
Cotinine
Cotrim
Coumadin
Cozaar
Crestor
Crospovidone
Cuprimine
Cyanocobalamin
Cyclessa
Cyclizine
Cyclobenzaprine
Cyclopentolate
Cyclophosphamide
Cyclopropane
Cylert
Cyproterone
Cystagon
Cysteine
Cytarabine
Cytotec
Cytovene
Isotretinoin
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Read more at Wikipedia.org


[List your site here Free!]


Vaccine—derived poliovirus, Thailand, 2003
From Emerging Infectious Diseases, 5/1/05 by Piyanit Tharmaphornpilas

To the Editor: The Polio Eradication Campaign was started in Thailand in 1990, and the last polio case was reported in April 1997. Although no new cases have been reported, the Polio Eradication Campaign continues with 4 prevention strategies: high coverage with 3 doses of oral polio in children <1 year of age, acute flaccid paralysis surveillance, acute flaccid paralysis case investigation and response, and National Immunization Day. Also, the Ministry of Public Health is prepared for a national emergency response to polio importation and circulated vaccine-derived poliovirus (1).

In April 2003, a case of acute flaccid paralysis was reported from Phakhao district, Loei province. The patient was an 18-month-old boy with normal physical development and nutritional status. He had a history of mild asthma and had received bronchodilator drugs occasionally during upper respiratory tract infections in the past. The patient had been fully vaccinated. He had received a total of 5 doses of oral polio vaccine: a dose at 2, 4, and 6 months of age, and 2 doses on National Immunization Day in December 2002 and January 2003.

On March 27, 2003, while visiting his grandmother in Phoowiang district, Khonkaen province (80 km from his residence), the patient became ill. Pneumonia was diagnosed; injected medications were administered into his left hip once a day for 3 days. The patient fully recovered.

On April 1, 2003, cellulitis of finger developed in the patient. The affected finger was incised and drained, and oral antimicrobial drugs were administered. The inflammation extended to his elbow but later subsided.

On April 7, fever, cough, and dyspnea developed in the patient. Two days later, the patient's left leg became weak. He was admitted to Phakhao Hospital with a diagnosis of pneumonia and with weakness in his left leg. He was later referred to Loei Provincial Hospital and acute flaccid paralysis was diagnosed on April 11. The muscle weakness progressed until he could not sit.

On April 14, the patient was referred to Khonkaen Regional Hospital with weakness in both legs and arms (grade 0-1). Chest radiograph showed perihilar pneumonia. Cloxacillin, gentamicin, and immunoglobulin (Ig) (6 g/day x 4 days, patient weight 12 kg) were administered intravenously to the patient. He was discharged on April 30 with a diagnosis of Guillain-Barre syndrome and bacterial pneumonia. The muscle tone in his right leg and both arms was grade 3; however, he could not move his left leg.

Stool samples were collected on April 11 and 14 and tested for polio at the Department of Medical Science (reference laboratory for polio in Southeast Asia). Poliovirus type 2 was isolated in the samples; however, the results were inconclusive for strain differentiation. The isolates were sent to the Centers for Disease Control and Prevention (CDC), USA, for genetic sequencing, and the result showed poliovirus type 2 with 1.6% difference from Sabin strain poliovirus. Without evidence of recombination with other nonpolio enterovirus, the pattern of genomic change was similar to the change that occurs in immunodeficient persons. Immune system testing of the patient on August 13 showed IgG = 205.9 mg/dL (normal 800-1,700), IgA <5.5 mg/dL (normal 100-490), IgM <16.8 mg/dL (normal 50-320), and IgE <18.0 mg/dL (normal 0-100). Anti-bodies to poliovirus type 1, 2, and 3 were 1:16, 1:32, and 1:8, respectively. Testing of the follow-up stool samples showed P1/Sabin on August 10. Test results were negative on October 13, and results showed nonpolio enterovirus on November 10 and December 14.

Before the large-scale outbreak response immunization was conducted, 339 serum samples were collected from children <5 years of age who lived in the same district as the patient or in the same subdistrict as his grandmother. Among 153 children who brought their vaccination records, the median dose of oral polio vaccine was 7 (range 2-15). All had antibody >1:8 to poliovirus types 1, 2, and 3. Approximately 2,000 stool samples were collected from children <5 year of age who lived in the same district as the case-patient or his grandmother. However, after the immunodeficiencies vaccine--derived poliovirus was identified, isolation of the virus was attempted only from stool samples from children who lived in the same subdistrict as the patient. From 223 stool samples, 4 Sabin strain poliovirus and 32 nonpolio entero-viruses were isolated. In addition, 2 of 18 stool samples collected in July from close contacts of the case-patient were positive for Sabin strain poliovirus and negative for vaccine-derived poliovirus.

The Loei Provincial Health Office initially did a small-scale response immunization in 3 adjacent villages (128 of 129 children) on the day that the case of acute flaccid paralysis was reported. Coverage of third dose of oral polio vaccine in these villages was 100%. No response immunization was conducted at the village in Khonkaen. On August 8, genetic sequencing results showed vaccine derived poliovirus; the decision was made to launch an outbreak response immunization for 175,000 children <5 years of age living in Loei, Khonkaen, and Nongbualampoo provinces (visited by the patient from March to August 2003). Two-round campaigns were conducted in August and September. The estimated vaccine coverage was >95%.

Considering the rate of 1% genomic diversity per year and the immunodeficient status of the patient (2), he should have harbored the vaccine strain virus since he received the first dose of routine oral polio vaccine immunization at 2 months of age, and the virus was replicated in his gut. However, why the virus disappeared in subsequent stool specimens is unknown. Circulating vaccine--derived poliovirus is unlikely in this event, as we found no evidence of recombination with other nonpolio enterovirus, high oral polio vaccine coverage in the community, and no vaccine derived poliovirus in other children.

Although immunoglobulin levels in this case were tow but still detectable, whether the patient's illness was agamnaaglobulinemia or hypogammaglobulinemia is uncertain. The detected immunoglobulin levels, as well as the antibody level to poliovirus, may be due to intravenous imlnunoglobulin (IVIG) the patient received while hospitalized 4 months before testing. Since August 2003, the patient has been on IVIG replacement therapy after prolonged and repeated respiratory tract infections.

In retrospect, problems surrounded this event. First, because of several attempts to confirm the result, identification of strain differentiation was delayed. Second, genetic sequencing was delayed because of a communication gap associated with new bioterrorism regulations in the United States during specimen transfer. Third, knowledge of a possible immune deficiency in the previously healthy child was lacking, testing for the patient's immune status was delayed.

Acknowledgment

We thank Siriraj Hospital, the Centers for Disease Control and Prevention, and Suchitra Nimmannitya.

(1) Expanded Programme on Immunization, Department of Disease Control; Khonkaen Provincial Health Office, Permanent Secretary Office; Loei Provincial Health Office, Permanent Secretary Office; Nongbualampoo Provincial Health Office, Permanent Secretary Office; Polio Eradication Campaign, Department of Disease Control; Senior Public Health Inspector General Office, Permanent Secretary Office; Virus Research Institute, Department of Medical Science.

References

(1.) Division of General Communicable Disease. Ministry of Public Health. National documentation liar certification of poliomyelitis eradication. Thailand, 2003 [official document].

(2.) Khetsuriani N. Prevots DR. Quick L, Elder ME, Pallansch M, Kew O. et al. Persistence of vaccine--derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis. J Infect Dis. 2003:188:1845-52.

Piyanit Tharmaphornpilas * for the outbreak Response Team, Thailand

* Ministry of Public Health, Nonthaburi, Thailand

Address tier correspondence: Piyanit Tharmaphornpilas, EPI manager. Department of Disease Control, Ministry of Public Health, Nonthaburi, 11000, Thailand: fax: 66-2-5918425: email: piyanit@health.moph.go.th

COPYRIGHT 2005 U.S. National Center for Infectious Diseases
COPYRIGHT 2005 Gale Group

Return to Cloxacillin
Home Contact Resources Exchange Links ebay