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Coccidioidomycosis

Coccidioidomycosis (also known as Valley fever and California valley fever) is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii. It is endemic in certain parts of Arizona, California, Nevada, New Mexico, Texas, Utah and northwestern Mexico. more...

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C. immitis resides in the soil in certain parts of the southwestern United States, northern Mexico, and a few other areas in the Western Hemisphere. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, which are a form of spore. The disease is not transmitted from person to person.

Symptomatic infection (40% of cases) usually presents as an influenza-like illness with fever, cough, headaches, rash, and myalgias. Some patients fail to recover and develop chronic pulmonary infection or widespread disseminated infection (affecting meninges, soft tissues, joints, and bone). Severe pulmonary disease may develop in HIV-infected persons.

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EXPERIMENTAL VACCINES AGAINST COCCIDIOIDOMYCOSIS
From Revista do Instituto de Medicina Tropical de Sao Paulo, 10/1/05 by Cole, G T

Cole, G.T.

Medical College of Ohio, USA

Coccidioides is a fungal pathogen of humans which can cause a life-threatening respiratory disease in immunocompetent individuals. Recurrent epidemics of coccidioidal infections in Southwestern United States has raised the specter of awareness of this soilborne microbe, particularly among residents of Arizona and Southern California, and has galvanized research efforts to develop a human vaccine against coccidioidomycosis. The focus of our studies of candidate vaccines has been the identification of purified, recombinant antigens which elicit a potent and durable host protective response against Coccidioides infection. The strategies used to identify and evaluate vaccine candidates will be discussed, and an update on progress toward development of a vaccine against this endemic pathogen will be presented.

Copyright Instituto de Medicina Tropical de Sao Paulo Oct 2005
Provided by ProQuest Information and Learning Company. All rights Reserved

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