An eye with viral conjunctivitis
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Conjunctivitis

Conjunctivitis (commonly called "pinkeye") is an inflammation of the conjunctiva (the outermost layer of the eye and the inner surface of the eyelids), often due to infection. There are three common varieties of conjunctivitis, viral, allergic, and bacterial. Other causes of conjunctivitis include thermal and ultraviolet burns, chemicals, toxins, overuse of contact lenses, foreign bodies, vitamin deficiency, dry eye, dryness due to inadequate lid closure, exposure to chickens infected with Newcastle disease, epithelial dysplasia (pre-cancerous changes), and some conditions of unknown cause such as sarcoidosis. more...

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Blepharoconjunctivitis is the combination of conjunctivitis with blepharitis.
Keratoconjunctivitis is the combination of conjunctivitis and keratitis.

Epidemiology

Viral conjunctivitis is spread by aerosol or contact of a variety of contagious viruses, including many that cause the common cold, so that it is often associated with upper respiratory tract symptoms. Clusters of cases have been due to transfer on ophthalmic instruments which make contact with the eye (e.g., tonometers) and have not been adequately sterilised.

Allergic conjunctivitis occurs more frequently among those with allergic conditions, with the symptoms having a seasonal correlation. It can also be caused by allergies to substances such as cosmetics, perfume, protein deposits on contact lenses, or drugs. It usually affects both eyes, and is accompanied by swollen eyelids.

Bacterial conjunctivitis is most often caused by pyogenic bacteria such as Staphylococcus or Streptococcus from the patient's own skin or respiratory flora. Others are due to infection from the environment (eg insect bourne), from other people (usually by touch- especially in children), but occasionally via eye makeup or facial lotions. An example of this is conjunctivitis due the the bacteria Haemophilus influenzae biogroup aegyptius.

Irritant, toxic, thermal and chemical conjunctivitis are associated with exposure to the specific agents, such as flame burns, irritant plant saps, irritant gases (e.g., chlorine or hydrochloric acid ('pool acid') fumes), natural toxins (e.g., ricin picked up by handling castor oil bean necklaces), or splash injury from an enormous variety of industrial chemicals, the most dangerous being strongly alkaline materials.

Xerophthalmia is a term that usually implies a destructive dryness of the conjunctival epithelium due to dietary vitamin A deficiency—a condition virtually forgotten in developed countries, but still causing much damage in developing countries. Other forms of dry eye are associated with aging, poor lid closure, scarring from previous injury, or autoimmune diseases such as rheumatoid arthritis, and these can all cause chronic conjunctivitis.

Diagnosis

Symptoms

Redness, irritation and watering of the eyes are symptoms common to all forms of conjunctivitis. Itch is variable.

Acute allergic conjunctivitis is typically itchy, sometimes distressingly so, and the patient often complains of some lid swelling. Chronic allergy often causes just itch or irritation, and often much frustration because the absence of redness or discharge leads to accusations of hypochondria.

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Selecting a topical treatment for seasonal allergic conjunctivitis
From American Family Physician, 4/1/05 by Anne D. Walling

Approximately one fifth of the population in the United Kingdom suffers from seasonal allergic conjunctivitis. Symptoms of ocular irritation, redness, and tearing (frequently accompanied by nasal symptoms) typically occur during pollen- producing seasons. As the underlying mechanism of this condition is believed to be a type 1, IgE-mediated hypersensitivity, topical mast cell stabilizers and antihistamines are used to control symptoms. Systemic antihistamines may be prescribed for patients with more widespread symptoms, and steroids are used occasionally in severe cases. Owen and colleagues con-ducted a systematic review to determine the relative effectiveness of topical mast cell stabilizers and antihistamines in symptomatic therapy for seasonal allergic conjunctivitis.

Electronic databases, including the Cochrane Library, and bibliographies of relevant articles were used to identify clinical trials comparing topical mast cell stabilizers or antihistamines with placebo, and these two classes of agents with one another. Of the 140 original studies identified, 40 met quality criteria for inclusion in the meta-analysis.

Placebo-controlled trials of the mast cell stabilizers sodium cromoglycate, nedocromil, and lodoxamide were identified. The 17 studies of sodium cromoglycate tended to involve small numbers of patients, differed in outcome measures, and showed evidence of publication bias. Nevertheless, the authors calculate a significant difference in perceived benefit over placebo with no important side effects. Patients also perceived significant improvement in symptoms in three of the five trials of topical nedocromil. The authors calculate that patients treated with this drug were 1.8 times more likely to report moderate or complete control of symptoms than patients given the placebo. A significant benefit also was reported for topical lodoxamide compared with placebo, but this was based on one small study. In the pooled analysis of the 12 topical mast cell stabilizer studies, patients were 4.9 times more likely to report symptom relief compared with placebo.

Nine studies comparing topical antihistamines with placebo were identified. Six of these studies used levocabastine, and the remaining studies involved azelastine, emedastine, and antazoline. Most studies used subjective symptom scales completed by patients after provocation, and results showed symptom improvement, especially in itching. A formal meta- analysis was not possible because of study designs.

Eight trials compared the effectiveness of topical mast cell stabilizers with topical antihistamine. A formal meta- analysis was not possible because of differences in the reporting of outcomes. The topical antihistamine appeared to reduce symptoms better than mast cell stabilizers in short-term provocation studies and showed limited evidence of a faster onset of action. Otherwise, no significant differences were apparent between the classes of medication.

The authors conclude that topical mast cell stabilizers and antihistamines provide significantly better symptom relief than placebo in allergic conjunctivitis. Based on available evidence, the choice of a specific agent should be determined by factors such as convenience of use, cost, and patient preferences.

Owen CG, et al. Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness. Br J Gen Pract June 2004;54:451-6.

COPYRIGHT 2005 American Academy of Family Physicians
COPYRIGHT 2005 Gale Group

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