Cowpox virus
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Cowpox

Cowpox is a disease of the skin caused by a virus (Cowpox virus) that is related to the Vaccinia virus. The ailment manifests itself in the form of red blisters and is transmitted by touch from cows to humans. The virus that causes cowpox was used to perform the first successful vaccination against another disease. The disease vaccinated against was the deadly smallpox, which is caused by the related Variola virus. Therefore the word "vaccination" has the Latin root vaca meaning cow. more...

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In 1798 the rural English physician Edward Jenner made a curious observation. His patients who had contracted and recovered from cowpox, a disease similar to but much milder than smallpox, seemed to be immune not only to further cases of cowpox, but also to smallpox. By scratching the fluid from cowpox lesions into the skin of healthy individuals, he was able to immunize those people against smallpox.

The Cowpox (Catpox) virus is found in Europe and mainly in the UK. Human cases are very rare and most often contracted from domestic cats. The virus is not commonly found in cows; the reservoir hosts for the virus are woodland rodents particularly voles. It is from these rodents that domestic cats contract the virus. Symptoms of infection with cowpox virus in humans are localized, pustular lesions generally found on the hands and limited to the site of introduction. The incubation period is 9-10 days. The virus is prevalent in late summer and autumn.

Historical use

Cowpox was the original vaccine of sorts for smallpox. after infection with the disease, the body (usually) gains the ability of recognising the similar small pox virus from its antibodies and so is able to fight the smallpox disease much more efficiently.

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Japanese color woodcut print advertising the effectiveness of cowpox vaccine - Brief Article
From Emerging Infectious Diseases, 11/1/00

In 1849, 18 years before the Meiji Revolution, cowpox vaccination was first successful in Nagasaki, which was the only city open to foreign visitors during the Tokunaga Era. This method became widespread throughout Japan. Dr. Ryusai Kuwata (Bunka 8/1811-Keio 4/1868) from Edo (modern Tokyo) made this color woodcut print to advertise the effectiveness of the vaccination to protect against smallpox; he used this picture at the Osaka Vaccination Clinic. The white cow in the print represents vaccination.

It was known that among persons and families who tended cows, the clinical signs of smallpox were never serious. Following this clue, Dr. Kuwata tried vaccinating children with the contents of eruptions from cowpox. As a result, the children's illness was mild and not transmitted to others. Dr. Kuwata, who was the pioneer of vaccination in Japan, vaccinated more than 70,000 people. He died with a vaccination needle in his hand in 1868, when he was 58 years old.

COPYRIGHT 2000 U.S. National Center for Infectious Diseases
COPYRIGHT 2001 Gale Group

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