An image of a child with Lamdoid Cranial Synostosis. Notice the swelling on the right side of the head.A child wearing a cranial band.
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Craniosynostosis

Craniosynostosis is a medical condition in which the sutures in the skull of an infant close too early, causing problems with normal brain and skull growth. It can result in craniostenosis, which is the skull deformity caused by the premature closure of the cranial sutures. Also intracranial pressure can be increased. more...

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Normal skull development

In humans, the adult skull is normally made up of 28 bones. Except for the mandible, all of the bones of the skull are joined together by sutures, rigid articulations permitting very little movement.

At birth, the human skull is made up of 45 separate bony elements. As growth occurs, many of these bony elements gradually fuse together into solid bone (for example, the frontal bones).

The bones of the roof of the skull are initially separated by regions of dense connective tissue. At birth these regions are fibrous and moveable, necessary for birth and later growth. Larger regions of connective tissue, called fontanelles, occur where certain bony elements meet. As growth and ossification progress, the connective tissue of the fontanelles is invaded and replaced by bone. The posterior fontanelle usually closes by eight weeks, but the anterior fontanelle can remain up to eighteen months.

Pathophysiology

When one or more sutures fuse prematurely, skull growth can be restricted perpendicular to the suture. If multiple sutures fuse while the brain is still increasing in size, intracranial pressure can increase.

Primary craniosynostosis is believed to be a result of primary defect in the mesenchymal layer ossification in the cranial bones. Secondary craniosynostosis is a result of primary failure of brain growth.

Treatment

Surgery is typically used to seperate the fused sutures of the skull as well as to reshape the skull. Without surgery, blindness and mental retardation is a typical outcome. To treat the cosmetic troubles, a combination of orthodontic and orthognathic surgery can be used to relieve some of the midface deficiency.

Typical surgery begins with a zigzag incision from ear to ear across the top of the head. The scar left by this type of incision makes the hair look more natural than that left by a straight incision would. Raney clips are typically used to curtail bleeding, as cauterization would not result in an aesthetically pleasing result upon healing. Once the scalp is peeled back, pilot holes are drilled through the skull. These pilot holes are then connected, separating the skull into several pieces. Once reshaped, these pieces are placed back on the head (typically in an altered configuration) and held together by a combination of dissolving sutures, plates, and screws. These plates and screws are typically composed of a copolymer comprised of polyglycolic and polylactic acid and will break down into water and carbon dioxide within a year. Demineralized bone matrix is often used to fill gaps left by the expanded skull. Once the Raney clips are removed, dissolving sutures are again used to close the incision.

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The Clinical Management of Craniosynostosis (Clinics in Developmental Medicine (Mac Keith Press)) $80.75 Craniosynostosis : Diagnosis, Evaluation, and Management $148.00
Craniosynostosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95 Endoscopic strip craniectomy: a minimally invasive treatment for early correction of craniosynostosis. : An article from: Journal of Neuroscience Nursing $5.95
Fertility treatments and craniosynostosis: California, Georgia, and Iowa, 1993-1997. : An article from: Pediatrics $5.95 The Official Parent's Sourcebook on Craniosynostosis: A Revised and Updated Directory for the Internet Age $28.95
Advances and Technical Standards in Neurosurgery Vol. 29 (Advances and Technical Standards in Neurosurgery) $170.00 Early treatment best for skull abnormalities. (Rule Out Craniosynostosis First). : An article from: Pediatric News $5.95
Facial Clefts and Craniosynostosis: Principles and Management $340.03 Craniofacial Surgery for Craniosynostosis $48.50

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