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Cyclessa

Oral contraceptives come in a variety of formulations. The main division is between combined oral contraceptive pills, containing both estrogen and progesterone, and progesterone only pills (mini-pills). Combined oral contraceptive pills also come in varying types, including varying doses of estrogen, and whether the dose of estrogen or progesterone changes from week to week. more...

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Combined oral contraceptive pills

All contain the estrogen ethinyl estradiol, although in varying amounts, and one of a number of different progesterones. They are taken for 21 days with then a 7 day gap during which a withdrawal bleed (often, but incorrectly, referred to as a menstrual period) occurs. These differ in the amount of estrogen given, and whether they are monophasic (only one dose of estrogen and progesterone during the 21 days) or multiphasic (varying doses).

Monophasic

These are given as 21 tablets of estrogen and progesterone, followed by 7 tablets of placebo. Different formulations contain different amounts of estrogen and progesterone:

  • 20 mcg estrogen
    • 0.1 mg levonorgestrel (Alesse®, Levline®)
    • 1 mg norethindrone acetate (Loestrin 1/20®Fe)
  • 30 mcg estrogen
    • 0.15 mg levonorgestrel (Levlen®, Levora®, Nordette®)
    • 0.3 mg norgestrel (Lo-Ovral®)
    • 0.15 mg desogestrel (Desogen®, Organon; Ortho-Cept®, Ortho-McNeil)
    • 1.5 mg norethindrone acetate (Loestrin® 1.5/30)
    • 3.0 mg drospirenone (Yasmin®)
  • 35 mcg estrogen
    • 0.25 mg norgestimate (Ortho-Cyclen®)
    • 0.4 mg norethindrone (Ovcon-35®, Warner Chilcott)
    • 0.5 mg norethindrone (Modicon®, Brevicon®)
    • 1 mg norethindrone (Ortho-Novum 1/35®, Necon®, Norethin®, Norinyl 1/35®)
    • 1 mg ethynodiol diacetate (Demulen 1/35®, Zovia 1/35E®)
  • 50 mcg estrogen
    • 0.4 mg norethindrone (Ovcon-50®, Warner Chilcott))
    • 1 mg norethindrone (Necon 1/50®, Norinyl 1/50®, Ortho-Novum 1/50®, Ovcon-50®)
    • 0.5 mg norgestrel (Ovral®)
    • 1 mg ethynodiol diacetate (Demulen 1/50®, Zovia 1/50E®)

Multiphasic

  • Desogestrel 0.15 mg and ethinyl estradiol 0.02 mg x 14 tablets, followed by ethynil estradiol 0.01 mg x 2 tablets, followed by 5 tablets of placebo (Kariva®, Barr Laboratories; Mircette®, Organon)
  • Desogestrel 0.1 mg ethynil estradiol 0.025 mg x 7 tablets, followed by desogestrel 0.125 mg and ethynil estradiol 0.025 mg x 7 tablets, followed by desogestrel 0.15 mg and ethynil estradiol 0.025 mg x 7 tablets, followed by 7 tablets of ferric oxide (Cyclessa®, Organon; Velivet®, Barr Laboratories)
  • Norethindrone 0.5 mg and ethinyl estradiol 0.035 mg x 7 tablets, followed by 0.75 mg of norethindrone and 0.035 mg of ethinyl estradiol x 7 tablets, followed by 1 mg of norethindrone and 0.035 of ethinyl estradiol, followed by 7 tablets of placebo (Ortho-Novum 7/7/7®)
  • Norethindrone 0.5 mg and 0.035 mg of ethinyl estradiol x 10 tablets, followed by 1 mg norethindrone and 0.035 ethinyl estradiol x 11 tablets, followed by 7 tablets of placebo (Ortho-Novum 10/11®)

Read more at Wikipedia.org


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Organon and Prasco Ink a Generic Supply Agreement for a Second Oral Contraceptive Product
From Business Wire, 8/30/04

CINCINNATI -- Prasco Laboratories

--Prasco will market the triphasic oral contraceptive desogestrel/ethinyl estradiol tablets under the name Cesia(TM)

--Cesia will be another important product in Prasco's growing line of Prasco Authorized Generics

--Cesia is therapeutically equivalent to the brand Cyclessa(R)

Prasco Laboratories, a privately-held pharmaceutical company located in Cincinnati, Ohio, announced today it has entered into an agreement with Organon Ireland Ltd. for Cesia(TM)(1) (desogestrel/ethinyl estradiol) Tablets. Cesia (pronounced SESH-ah) is an authorized generic oral contraceptive, therapeutically equivalent to the brand Cyclessa(R)(2) from Organon. Cesia will compete for generic sales with the first generic triphasic regimen product in this market segment.

"We are very pleased to expand our relationship with Organon and add Cesia to our growing Prasco Authorized Generic product line," said Prasco Chief Executive Officer E. Thomas Arington. "As a Prasco Authorized Generic, Cesia will provide brand quality at generic pricing. We expect Cesia to make a positive marketplace impact, offering pharmacists and consumers another alternative with distinct packaging benefits for both the pharmacist and the consumer."

About Prasco

Founded by Arington in 2002, Prasco's mission is to provide quality products and significant cost-savings to the consumer. Prasco is a leading multi-source marketing and distribution company that utilizes a versatile, horizontally-integrated business approach to efficiently link manufacturers to retailers to consumers. Prasco combines its intellectual property with the special capabilities of selected partners to realize opportunities and benefit consumers by finding and filling unmet needs within the pharmaceutical marketplace.

Prasco's goal is to lead the field in bringing to consumers Prasco Authorized Generics, which are brand products sold under private labels. Prasco's executive team has extensive experience working within both the brand and generic industries. A centerpiece of the company's corporate capabilities is its sales/marketing and business development teams. Prasco's product line is currently sold through the major distribution channels, including chains, wholesalers, and managed care providers.

The company operates from a 54,000 sq. ft. administrative office and warehouse facility and has complete control over product distribution management systems--including DEA-approved facilities for Schedule II-V controlled drug products.

About Organon

Organon - headquartered in Roseland, NJ, USA - creates and markets prescription medicines that improve the health and quality of human life. Through a combination of independent growth and business partnerships Organon strives to become or remain one of the leading pharmaceutical companies in each of its core therapeutic fields: reproductive medicine, psychiatry and anesthesia. Organon products are sold in over 100 countries, of which more than 60 have an Organon subsidiary. Organon is the human health care business unit of Akzo Nobel NV.

(1) Cesia(TM) is a trademark of Prasco, LLC.

(2) Cyclessa(R) is a registered trademark of Organon N.V. Organon, OSS The Netherlands

COPYRIGHT 2004 Business Wire
COPYRIGHT 2004 Gale Group

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