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Dacarbazine

Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma (a form of skin cancer which can spread to other parts of the body). Antineoplastic drugs are drugs which interfere with cell growth and impede the formation of new tissue - in this case, tumor tissue. These drugs are also known as cytotoxic drugs. Dacarbazine belongs to the family of chemicals known as alkylating agents. more...

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Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the the immediate supervision of a doctor or nurse.

History

Dacarbazine gained FDA approval in May 1975 as DTIC-Dome. The drug was initially marketed by Bayer.

Side effects

Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability of your body to fight infection or disease). Like most powerful drugs, it may produce more common side affects like nausea, fatigue, headache, etc.

Suppliers

Bayer continues to supply DTIC-Dome. There are also generic versions of dacarbazine available from APP, Bedford, Mayne Pharma and Sicor.

Sources

  • MedLine, U.S. National Institutes of Health, National Library of Medicine,
  • Cancerweb,
  • OncoLink,
  • WebMD,
  • ChemoCare,
  • SigmaAldrich Biochemicals,

Read more at Wikipedia.org


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Temozolomide vs. dacarbazine in stage IV metastatic melanoma
From Journal of Drugs in Dermatology, 11/1/05

This study is currently recruiting patients. Sponsors and Collaborators. Schering-Plough European Organization for Research and Treatment of Cancer. The purpose of this study is to ascertain if the extended schedule of Temozolomide, which allows increased doses and potential depletion of the enzyme under laying resistance, is a more effective treatment of metastatic melanoma than single agent dacarbazine.

Study ID Numbers: P03267

ClinicalTrials.gov Identifier: NCT00091572

COPYRIGHT 2005 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2005 Gale Group

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