Luis E. Miramontes signed laboratory notebook. October 15, 1951
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Desogestrel

A progestin is a synthetic progestagen. These particular synthetic hormones are most often used in the production of contraceptives. more...

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Progestins are classified according to their structure in C19 and C21 progestagens. The C19 ones are derived from testosterone, the C21 ones from progesterone. C21 progestagens include cyproterone acetate, dydrogesterone, medroxyprogesterone acetate, chlormadinone acetate, megestrol and promegestone. Of these, dydrogesterone is structurally most similar to progesterone. C19 progestagens include norethisterone, (levo)norgestrel, lynestrenol, desogestrel, norgestimate, gestodene and tibolone.

Different progestins have different combinations of androgen (testosterone-like) and progesterone activity. If the activity of 1 mg of norethindrone is taken as the baseline, 1 mg of the other progestins have activities as follows:


Norethindrone was synthetized for the first time in 1951 by the Mexican chemist Luis E. Miramontes. This substance became the basis for the contraceptive pill.

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Watson Pharmaceuticals
From Drug Store News, 9/26/05

Watson Pharmaceuticals last month received final approval from the FDA on its application for desogestrel and ethinyl estradiol tablets, the generic equivalents to Ortho-McNeil s Ortho-Cept and Organon's Desogen contraceptive products.

For the 12 months ended in March, desogestrel and ethinyl estradiol had total U.S. sales of approximately $180 million, according to IMS Health data.

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