Dextroamphetamine chemical structure
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Dexedrine

Dextroamphetamine (also known as dextroamphetamine sulfate, dexamphetamine, Dexedrine, Dextrostat, Dexampex, Ferndex, Oxydess II, Robese, Spancap #1, and, informally, Dex), a stereoisomer of amphetamine, is an indirect-acting stimulant that releases norepinephrine from nerve terminals, thus promoting nerve impulse transmission. It increases motor activity and mental alertness, and reduces drowsiness and a sense of fatigue. more...

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Clinical uses

Its only accepted indications are for children and adults with attention deficit hyperactivity disorder (ADHD) or well-established narcolepsy, generally where non-pharmacological measures have proved insufficient. In some localities it has replaced Ritalin as the first-choice pharmacological treatment of ADHD, of which it is considered an effective treatment. Dexedrine is contraindicated for patients with a history of substance abuse.

Certain studies have been performed regarding possible alternate use for antidepressant treatment for HIV patients with depression and debilitating fatigue, early stage physiotherapy for severe stroke victims, and treatment for those with methamphetamine (speed) addiction. Dextroamphetamine is also used to treat fatigue in cancer patients.

The drug comes in 5mg and 10mg tablets, or tabs, as well as 5mg, 10mg, and 15mg Spansules (Capsules, or caps). The most commonly used bioavailable form of dextroamphetamine is dextroamphetamine sulfate, which is a salt of d-amphetamine.

Side effects

Possible adverse effects of dexamphetamine include insomnia, reduced appetite, dependence, nervousness, restlessness, irritability, and euphoria that may be followed by fatigue and depression. There may be dryness of mouth, abdominal cramps, headache, dizziness, tremor, sweating, palpitations, increased or sometimes decreased blood pressure and altered libido. The Physician's 1991 Drug Handbook reports: "Symptoms of overdose include restlessness, tremor, hyperreflexia, tachypnea, confusion, aggressiveness, hallucinations, and panic."

There have also been reports of growth retardation of children with long-term use, although this effect can be reduced by alternating periods of abstinence from dexedrine.


As Dextroamphetamine is a stimulant, it is highly addictive and should be used with caution. The use of Dextroamphetamine for long periods of time may result in drug tolerance, and even physical dependence.

Addiction is relatively uncommon when used as prescibed, such as in cases of Attention Deficit Hyperactive Disorder and Narcolepsy. However, the drug is also widely used without a prescription, and can be abused for its sleep-inhibiting properties.
Dextroamphetamine is a Schedule II controlled substance, and possession without prescription is illegal. This is due to the extremely high potential for abuse, as well as the severe physical and psychological effects that can result from this.

Other uses

The US Air Force uses dextroamphetamine as its "go-pill." It is given to pilots on long missions to help them remain focused and alert. However, Dexedrine is being phased out in favor of Provigil as the Air Force's new go-pill.

Read more at Wikipedia.org


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Unstable Future
From Connection: New England's Journal of Higher Education, 7/1/04 by Harney, John O

The idea for this issue of CONNECTION began percolating a few years ago when I was visiting a doctoral class in higher education administration at Johnson & Wales University. I'd asked the aspiring college administrators which issues in academia they thought were being neglected by higher education journals and the mainstream media. One student lamented that so much ink is spilled on whether young people are ready for college academically, but hardly anyone pays attention to whether they are ready emotionally.

If this all sounded a bit soft for CONNECTION, it soon became clear that the topic has some very hard edges. Economists and psychologists increasingly recognize that emotional intelligences-the way people interpret and respond to social situations, how they handle criticism or failure, the way they deal with emotions, their own and those of others-are critical qualities in the postindustrial workplace. In fact, researchers in the field contend that one's emotional quotient or "EQ" is a much more accurate predictor of success in life than the more common IQ, and that organizations where emotional intelligence is nurtured see measurable improvements in performance. Moreover, one need only look at any organization's employee handbook to see that violence, substance abuse and sexual boundary-crossing are critical issues in today's workplace.

What then to make of New England's economic future when her college students respond to a Super Bowl or NCAA victory by torching the nearest car, when a large number of male students think the female word for "Yes" is "No" and when many students sink into depression and too many commit suicide?

The future "knowledge workers" of New England are a generation raised on WWF wrestling, "bring 'em on" presidential machismo and between 500 and 700 alcohol ads on TV per year. Four in 10 U.S. college students take psychoactive drugs such as Dexedrine, Prozac or Ritalin. Many of those students could not have made it to college without meds. But away from home, it's easy to forget to take them, or to abuse them, or to trade them with classmates.

All told, the range of social/emotional challenges facing college students-and, thereby, college administrators-does appear to constitute a regional human capital problem on the order of, say, lagging achievement in algebra.

The good news is that like algebra, emotional intelligence can be learned. Researchers have developed instruments to reliably measure EQ and college curricula to sharpen it-to help students adapt to change, work in teams, deal with adversity and so on.

College may come a bit late in the game to tackle the tougher student pathologies. But even these can be addressed with actions that go beyond American Council on Education General Counsel Sheldon E. Steinbach's recent deadpan advice to limit liability by "locking the bell tower and [locking] the prescription drugs in the athletic trainer's office. ..."

At MIT, where stressed-out students committed suicide at the rate of one per year during the 1990s, mental health services have been dramatically overhauled with special liaisons assigned to groups of students and unlimited outpatient psychotherapy visits made available. Dozens of colleges have signed up for a customized service called Ulifeline that provides online counseling for college students at risk of suicide.

Tufts University and the universities of Connecticut and Vermont, meanwhile, are among institutions that have received grants from the U.S. Justice Department in recent years under a Clinton administration initiative to address violence against women on college campuses.

To be sure, addressing student pathologies is also leading campus administrators into a brave new world. Some campuses are, in effect, deputizing networks of "peer educators" to deliver health messages in informal settings such as parties and sporting events. Before last winter's Super Bowl rioting, Northeastern University officials handed digital cameras to resident assistants. When the celebration went so badly, the university posted some of the photos on its web site to help identify the biggest troublemakers.

The emotional underdevelopment of college students will carry particularly highstakes, as the new economy relentlessly shifts jobs from place to place. And college administrators may find themselves in the ironic position of teaching students to be cool.

John O. Harney is executive editor of CONNECTION.

Copyright New England Board of Higher Education Summer 2004
Provided by ProQuest Information and Learning Company. All rights Reserved

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