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Dihydrocodeine

Dihydrocodeine, also called DHC or DF-118, is a synthetic opioid analgesic prescribed for postoperative pain, severe dyspnea, or as an antitussive. It was developed in the early 1900s, and is similar in chemical structure and pharmaceutical behaviour to codeine, but is approximately twice as potent. It has approximately 30% the potency of IM morphine. more...

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Although dihydrocodeine does have extremely active metabolites, in the form of dihydromorphine and dihydromorphine-6-glucuronide (100x more potent), these metabolites are produced in such small amount that they do not have clinically important effects2.

Indications

Approved indication for dihydrocodeine is the management of moderate to severe pain. It is usually formulated as tablets containing 30 mg with one tablet taken every 4-6 hours when necessary.

Dihydrocodeine is sometimes marketed in combination preparations with paracetamol (acetaminophen) as co-dydramol (BAN) to provide greater pain relief than either agent used singly (q.v. Drug Synergy).

Side Effects

As with other opioids, tolerance and physical and psychological dependence develop with repeated dihydrocodeine use. All opioids can impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving or operating machinery if taken in large doses, but have the opposite effect in moderate doses .

Regulation

In the USA, it is a DEA Schedule II substance, although preparations containing small amounts of dihydrocodeine are classified as Schedule III or Schedule V, depending on the concentration of dihydrocodeine relative to other active constituents, such as acetaminophen.

In the United Kingdom dihydrocodeine is a Class B drug - making it (in principle) more dangerous than cannabis which is a class C drug. Illegal possession of dihydrocodeine can result in up to 5 years in prison and/or an unlimited fine.

Read more at Wikipedia.org


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Drug misuse stems from a person's autonomy to choose - Letter to the Editor
From British Medical Journal, 4/24/99 by J M Hall

EDITOR--Robertson's critique of prison medical care of drug misusers would be valid if his fundamental proposition that drug misuse is a disease was held by all.[1] If this were the case then clearly medical practitioners would have a duty both to prevent the disease and to mitigate its sequelae.

Drug misuse is not a disease in the sense of an unfortunate assault on one's health. Rather, it stems from an individual's autonomy to choose whether or not to misuse drugs. Any medical input at this causal stage of choice could be viewed as beneficent paternalism and, from an ethical point of view, no more than that.

Drug misusers in custody do not always wish to seek medical help, so Robertson's inference that drug problems in prisons are "unacknowledged" itself needs rehabilitation. Even when prisoners are discharged, community practitioners rarely seek custodial medical information, which is always available on request. As I was drafting this letter, however, a medical practitioner did phone up regarding the treatment of a recently discharged drug misuser. He wanted to know if his patient had been receiving dihydrocodeine, zopiclone, and diazepam. The patient's record in fact showed that he had been taking tar based shampoo, and an antibiotic and an analgesic for a dental problem. Caution is needed in dealing with drug misusers; I wonder how this vignette supports or disproves Robertson's thesis.

Discharged patients rarely consent to their community practitioners having access to their custodial medical history--save where litigation is an issue. The prevalence of mental disorders in prisoners is well documented, so practitioners must explore fully the possibility of mental illness before opting for the more nebulous clinical option of post-traumatic stress syndrome.

Perhaps the Alcoholics Anonymous method of dealing with alcohol misuse should be applied, for here the autonomy of the patient to change his or her lifestyle is paramount. Using a medical model upholds the myth that addicts are the passive agent in a disease process over which they have no control.

JM Hall Senior medical officer

HM Prison, Winson Green, Birmingham B18 4AS

[1] Robertson R. Unacceptable practices: Prison to the community in one, totally unprepared, step. BMJ 1998; 317:757. (12 September.)

COPYRIGHT 1999 British Medical Association
COPYRIGHT 2000 Gale Group

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