Duloxetine chemical structure of duloxetine
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Duloxetine

Duloxetine hydrochloride (brand names: Cymbalta/Yentreve) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-
2-thiophenepropanamine, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE and 5-HT transport sites. more...

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Its behavior contrasts to most other dual-reuptake inhibitors in that Ki values are nearly 1:1.

Furthermore, duloxetine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours. Most common side effects in clinical trials were nausea, somnolence, and dry mouth. In clinical trials weight gain was neutral compared to placebo. Ongoing studies including a 52 week safety and efficacy trial are available at www.lillytrials.com. Long-term side-effects seen in these trials did not vary from the original approval studies.

Duloxetine is also approved by the FDA for the treatment of diabetic neuropathy. Approved dosages for treatment diabetic peripheral neuropathic pain are 60mg and 120mg once daily.

When used for the treatment of depression, the approved dosage is 40mg-60 mg once daily. Duloxetine is available in capsules of 20mg, 30mg, and 60mg.

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Duloxetine appears to ease pain of diabetic neuropathy in nondepressed patients.(Rx) : An article from: Internal Medicine News $5.95 Duloxetine relieves painful physical symptoms: investigational antidepressant.(Clinical Rounds)(Cymbalta from Eli Lilly and Co.)(Brief Article) : An article from: Family Practice News $5.95
Duloxetine may alleviate stress incontinence: drug under FDA review.(Rx) : An article from: Internal Medicine News $5.95

Duloxetine appears effective in treating fibromyalgia
VANCOUVER, B.C. -- Duloxetine is a safe and effective treatment for fibromyalgia symptoms in both depressed and nondepressed women, Lesley Arnold, M.D., ...
New molecular entity: Cymbalta®, Eli Lilly Duloxetine: SSNRI approved for treatment of MDD and diabetic peripheral neuropathic pain
Duloxetine, a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), has been approved for the treatment of major depressive disorder (MDD) ...
Duloxetine approved to treat diabetic peripheral neuropathy
After a 6-month priority review, the Food and Drug Administration last month approved duloxetine for managing pain associated with diabetic peripheral ...
Affects serotonin, norepinephrine: FDA approves duloxetine for the treatment of major depressive disorder
Approval of duloxetine hydrochloride by the Food and Drug Administration offers an additional drug for the treatment of major depressive disorder that ...
Duloxetine may improve stress incontinence: drug under FDA review - Gynecology
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