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Dystonia

Dystonia (literally, "abnormal muscle tone") is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. Dystonia may affect muscles throughout the body (generalised), in certain parts of the body (segmental), or may be confined to particular muscles or muscle groups (focal). more...

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Causes

Primary dystonia is caused by a pathology of the central nervous system, likely originating in those parts of the brain concerned with motor function, such as the basal ganglia. The precise cause of primary dystonia is unknown. In many cases it probably involves some genetic predisposition towards the disorder combined with environmental conditions.

Secondary dystonia refers to dystonia brought on by some identified cause, usually involving brain damage or chemical imbalance. Some cases of (particularly focal) dystonia are brought on after trauma, are induced by certain drugs (tardive dystonia), or may be the result of diseases of the nervous system such as Wilson's disease.

Symptoms

Symptoms vary according to the kind of dystonia involved. In all cases, dystonia tends to lead to abnormal posturing, particularly on movement. For many sufferers, pain is also a feature of the condition.

Types of Dystonia

  • Generalised
  • Segmental
  • intermediate

The Focal Dystonias

These are the most common dystonias and tend to be classified as follows:

  • Cervical dystonia (spasmodic torticollis). This affects the muscles of the neck, causing the head to rotate to one side, to pull down towards the chest, or back, or a combination of these postures.
  • Blepharospasm. This affects the muscles around the eyes. The sufferer experiences rapid blinking of the eyes or even their forced closure causing effective blindness.
  • Oromandibular dystonia. This affects the muscles of the jaw and tongue, causes distortions of the mouth and tongue.
  • Spasmodic dysphonia. This affects the muscles of the larynx, causing the voice to sound broken or reducing it to a whisper.

The combination of blepharospasmodic contractions and oromandibular dystonia is called Meige's syndrome.

Treatment

Drugs, such as anticholinergics which act as an inhibitor of the neurotransmitter acetylcholine, may provide some relief. However, for most sufferers their effects are limited. Botulinum toxin injections into affected muscles have proved quite successful in providing some relief for around 3-6 months, depending on the kind of dystonia. The injections have to be repeated and around 15% of recipients develop immunity to the toxin. Surgery, such as the denervation of selected muscles, may also provide some relief. Recently, the procedure of deep brain stimulation has proved successful in a number of cases of severe generalised dystonia.

One type of Dystonia, Dopa-Responsive Dystonia can be completely treated with regular doses of Levadopa/Carbidopa (Simnet). Although this doesn't remove the condition, it does alleviate the symptoms most of the time.

Read more at Wikipedia.org


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Dystonia
From SciTech Book News, 9/1/05

Dystonia.

Ed. by Joseph Jankovic et al.

Demos Medical Publishing, Inc.

2005

56 pages

$39.95

Paperback

RC935

Jankovic (Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine) provides a review of dystonia, a neurologic disorder, emphasizing cost-effective evaluation and treatment. The book will be of particular value to physicians and other health care providers in developing countries with limited diagnostic and therapeutic resources. Contributors balance the advantages of the latest technologies and treatments against the practicality of the "real world" situation facing these health care providers as they evaluate patients with dystonia and related movement disorders.

([c] 2005 Book News, Inc., Portland, OR)

COPYRIGHT 2005 Book News, Inc.
COPYRIGHT 2005 Gale Group

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