Ehlers-Danlos syndrome is a group of rare genetic disorders that diminish the body's ability to make connective tissues. It is caused by the inability of the body to synthesize different collagen types or a defect in synthesis. Depending on the individual mutation, the severity of the disease can vary from extremely mild to life-threatening. There is no known cure, other than symptomatic treatments. more...
Common symptoms are unstable, flexible joints with a tendency to dislocate and subluxate, due to ligaments which are overly stretchable, and elastic, fragile, soft skin that easily forms welts and scars. "It was the recommendation of a workshop convened in Berlin by Beighton (1986) that the Ehlers-Danlos designation be used for joint hypermobility with skin changes" in contrast to hypermobility syndromes without skin changes, once known as EDS type 11 (OMIM 147900). Other symptoms can include eye problems and nearsightedness. Bone deformities such as pectus excavatum (sunken chest) or scoliosis may present early. Most serious are vascular and organ fragility, which are thankfully less frequent.
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