Amitriptyline chemical structure
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Elavil

Amitriptyline hydrochloride (sold as Elavil®, Tryptanol®, Endep®) is a tricyclic antidepressant drug. It is a white, odorless, crystalline compound which is freely soluble in water and usually dispensed in tablet form. The empirical formula of its hydrochloride salt is C20H23N·HCl. more...

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Mechanism of Action

Amitriptyline affects serotonin and noradrenaline reuptake almost equally.

Uses

Approved

Amitriptyline is approved for the treatment of endogenous depression and involutional melancholia (depression of late life, which is no longer seen as a disease in its own right), and reactive depression and for depression secondary to alcoholism and schizophrenia.

Unapproved/Off-Label/Investigational

Amitriptyline may be prescribed for other conditions such chronic pain, postherpetic neuralgia (persistent pain following a shingles attack), fibromyalgia, interstitial cystitis, or irritable bowel syndrome.

A randomized controlled trial published in June of 2005 found that amitriptyline was effective in functional dyspepsia refractory to famotidine and mosapride combination therapy.

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More remedies for migraines
From Saturday Evening Post, 1/1/06 by Cory SerVaas

Dear Dr. SerVaas,

I had severe migraines for over 20 years. Then I read about peanut butter allergies sometimes causing migraines. Since I was an avid user of peanuts and peanut butter--almost daily--I eliminated them from my diet.

The migraines faded away. I'm 90 percent free of the migraine problem, no longer suffering from debilitating attacks. Perhaps this information can help others.

Billie James

Riggins, Idaho

Dear Dr. SerVaas,

At the age of 50, I was finally directed to a neurologist who was successful in getting rid of migraines. After trying different strengths, we came up with satisfactory doses of Elavil (one 25 mg tablet at bedtime) and Inderal (one 40 mg tab, twice a day, morning and night), with no side effects.

I am happy to write today that I have not had a migraine since I was 50 years old. I am now 72. Between my medical insurance and Medicare, the medications are free.

I thank the Lord that I found these medications. They have changed my life. I pray they will help someone else.

Joy Carson

Lutz, Florida

Thank you for sending us your migraine therapy. Like you, others have written that combining an antidepressant such as Elavil and a beta-blocker heart drug like Inderal may have helped. Readers have also reported that a daily regimen of anti-inflammatory or anti-convulsant medicines have reduced the frequency and severity of their headaches.

COPYRIGHT 2006 Saturday Evening Post Society
COPYRIGHT 2006 Gale Group

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