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Elephantiasis

Elephantiasis is a parasitic disease which is transmitted from human to human by mosquito bites. The parasite tends to lodge in and block the lymph nodes that drain into the lower extremities, producing massive enlargement and deformity of the legs and genitalia. Dramatic photographs of those affected appear in every infectious disease text. more...

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Medicines

Organisms that cause the disease are Wuchereria bancrofti, Brugia malayi, and B. timori, all transmitted by mosquitoes. Lymphatic filariasis currently affects 120 million people worldwide, and 40 million of these people have been seriously infected with the disease, which is extremely rare in the Western countries, and is found almost exclusively in the tropics. The disease is also called bancrofitan filariasis and lymphatic filariasis. Brugia malayi causes a similar disease, while Onchocerca volvulus causes many disorders in addition to elephantiasis.

Elephantiasis should not be confused with Proteus syndrome, a completely different disorder partly responsible for the deformity of the "Elephant Man" Joseph Merrick.

Treatment

Medicines to treat lymphatic filariasis are most effective when used soon after infection, but they do have some toxic side effects. In addition, the disease is difficult to detect early. Therefore, improved treatments and laboratory tests are needed. A vaccine is not yet available.

Antibiotics as a possible Treatment

In June 2005, a new study from the Liverpool School of Tropical Medicine reported that common antibiotics such as doxycycline may be effective in treating elephantiasis. The parasites responsible for elephantiasis have a population of symbiotic bacteria, wolbachia, that live inside the worm. When the symbiotic bacteria are killed by the antibiotic, the worms themselves also die.

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Elephantiasis nostrum verrucosa of the abdomen: clinical results with tazarotene.(CASE REPORTS) : An article from: Journal of Drugs in Dermatology $5.95 Gale Encyclopedia of Medicine : Elephantiasis $5.99
Elephantiasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $28.95 Podoconiosis : Non-filarial Elephantiasis (Oxford medical publications) $87.52
Elephantiasis A Medical Dictionary $32.71 Mosquito: A Natural History of Our Most Persistent & Deadly Foe $125.00
Studies on onchocerciasis and elephantiasis in Ethiopia Observations on morbid poisons, chronic and acute: The first comprehending syphilis, yaws, sivvens, elephantiasis, and the anomala confounded with them. ... particularly the variolous & vaccine
Biology of elephantiasis, lymphatic filariasis and albendazole: Index of new information Filariasis and elephan tiasis in Fiji: Being a report to the London School of Tropical Medicine (Supplement no. 1 of the Journal of the London School of Tropical Medicine)

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