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Eligard

Leuprolide is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary GnRH receptors, it intially causes stimulation (flare), but thereafter decreases pituitary secretion (downregulation) of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). more...

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Like other GnRH agonists, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat precocious puberty, and to control ovarian stimulation in IVF.

Leuprolide acetate is marketed by Bayer AG under the brand name Viadur, by Sanofi-Aventis under the brand name Eligard, and by TAP Pharmaceuticals under the brand name Lupron.

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Treatment for prostate cancer gets under the skin
From Nursing, 11/1/02

ELIGARD

Atrix Laboratories has received FDA approval for a 3-month sustained-release treatment for advanced prostate cancer. Indicated for palliative treatment, Eligard 22.5 mg (leuprolide acetate for injectable suspension) suppresses tumor growth in patients with hormoneresponsive prostate cancer. Injected S.C., the drug forms a solid implant under the skin. The drug is slowly released over 3 months as the implant is absorbed. This follows the January approval of Eligard 7.5 mg, which releases leuprolide over 1 month. Sustained levels of leuprolide decrease testosterone, which encourages growth of hormone-responsive tumors.

Eligard 22.5 mg will be copromoted with Atrix by Sanofi-Synthelabo.

Copyright Springhouse Corporation Nov 2002
Provided by ProQuest Information and Learning Company. All rights Reserved

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